Population genomic analyses of high-altitude humans and other vertebrates have identified
numerous candidate genes for hypoxia adaptation, and the physiological pathways …

In mammals and other air-breathing vertebrates that live at high altitude, adjustments in
convective O 2 transport via changes in blood hemoglobin (Hb) content and/or Hb-O 2 …

Tibetan sheep were introduced to the Qinghai Tibet plateau roughly 3,000 BP, making this
species a good model for investigating genetic mechanisms of high-altitude adaptation over …

Primates have adapted to numerous environments and lifestyles but very few species are
native to high elevations. Here we investigated high-altitude adaptations in the gelada …

Population genomic studies of humans and other animals at high altitude have generated
many hypotheses about the genes and pathways that may have contributed to hypoxia …

The grassland in the Qinghai–Tibetan plateau provide habitat for many indigenous and
introduced ruminants which perform important ecological functions that impact the whole …

Chronic hypoxia leads to irreversible cognitive impairment, primarily due to hippocampal
neurodegeneration, for which the underlying mechanism remains poorly understood. We …

Important questions about mechanisms of physiological adaptation concern the role of
phenotypic plasticity and the extent to which acclimatization responses align with genetic …

The ability to respond rapidly to changes in oxygen tension is critical for many forms of life.
Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and …

When proteins evolve new activity, a concomitant decrease in stability is often observed
because the mutations that confer new activity can destabilize the native fold. In the …