Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1
Focal segmental glomerulosclerosis (FSGS) is a frequent and severe glomerular disease
characterized by destabilization of podocyte foot processes. We report that transgenic …
characterized by destabilization of podocyte foot processes. We report that transgenic …
Atoh8 in development and disease
SSK Divvela, D Saberi, B Brand-Saberi - Biology, 2022 - mdpi.com
Simple Summary bHLH transcription factors control a variety of functions during
development and disease. Atoh8 is one such bHLH factor with unique characteristics in the …
development and disease. Atoh8 is one such bHLH factor with unique characteristics in the …
The role of atonal factors in mechanosensory cell specification and function
Atonal genes are basic helix-loop-helix transcription factors that were first identified as
regulating the formation of mechanoreceptors and photoreceptors in Drosophila. Isolation of …
regulating the formation of mechanoreceptors and photoreceptors in Drosophila. Isolation of …
Advances in the biology and genetics of the podocytopathies: implications for diagnosis and therapy
Context.—Etiologic factors and pathways leading to altered podocyte phenotype are clearly
numerous and involve the activity of different cellular function. Objective.—To focus on …
numerous and involve the activity of different cellular function. Objective.—To focus on …
[HTML][HTML] APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8
SM Madhavan, JF O'toole, M Konieczkowski… - JCI insight, 2017 - ncbi.nlm.nih.gov
APOL1 variants in African populations mediate resistance to trypanosomal infection but
increase risk for kidney diseases through unknown mechanisms. APOL1 is expressed in …
increase risk for kidney diseases through unknown mechanisms. APOL1 is expressed in …
A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC
Metastases are the main cause of cancer-related mortality in breast cancer. Although
significant progress has been made in the field of tumor metastasis, the exact molecular …
significant progress has been made in the field of tumor metastasis, the exact molecular …
The role of Hath6, a newly identified shear-stress-responsive transcription factor, in endothelial cell differentiation and function
F Fang, SM Wasserman… - Journal of cell …, 2014 - journals.biologists.com
The key regulators of endothelial differentiation that is induced by shear stress are mostly
unclear. Human atonal homolog 6 (Hath6 or ATOH8) is an endothelial-selective and shear …
unclear. Human atonal homolog 6 (Hath6 or ATOH8) is an endothelial-selective and shear …
Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network
Background Basic helix-loop-helix (bHLH) transcription factors play important roles in
differentiation processes during embryonic development of vertebrates. In the pancreas, the …
differentiation processes during embryonic development of vertebrates. In the pancreas, the …
The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development
GATA and Friend of GATA (FOG) form a transcriptional complex that plays a key role in
cardiovascular development in both fish and mammals. In the present study we demonstrate …
cardiovascular development in both fish and mammals. In the present study we demonstrate …
Zebrafish atoh8 mutants do not recapitulate morpholino phenotypes
Atoh8 is a bHLH transcription factor expressed in pancreas, skeletal muscle, the nervous
system, and cardiovascular tissues during embryological development. Although it has been …
system, and cardiovascular tissues during embryological development. Although it has been …