The past two decades have seen a worldwide resurgence in infections caused by
Treponema pallidum subsp. pallidum, the syphilis spirochete. The well-recognized capacity …

How can single cells without nervous systems perform complex behaviours such as
habituation, associative learning and decision making, which are considered the hallmark of …

Clustering of proteins into micrometer-sized structures at membranes is observed in many
signaling pathways. Most models of clustering are specific to particular systems, and …

Type IV pili are part of a widespread superfamily of bacterial and archaeal cell surface
structures important for biofilm formation, motility, host adhesion, predation, DNA uptake …

Superresolution fluorescence microscopy and cryogenic electron tomography (CET) are
powerful imaging methods for exploring the subcellular organization of biomolecules …

Chemotactic responses in bacteria require large, highly ordered arrays of sensory proteins
to mediate the signal transduction that ultimately controls cell motility. A mechanistic …

Electron cryotomography (ECT) enables intact cells to be visualized in 3D in an essentially
native state to'macromolecular'(∼ 4 nm) resolution, revealing the basic architectures of …

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that
protein interactions act as sophisticated data processing networks that govern intracellular …

Bacteria sense and respond to their environment through a highly conserved assembly of
transmembrane chemoreceptors (MCPs), the histidine kinase CheA, and the coupling …

In most signal transduction systems, coupling or scaffold proteins establish crucial
connections between receptors and histidine kinases. These connections are important for …