Pioneered by Huisgen in the 1960s, 1 the 1, 3-dipolar cycloaddition reaction between
acetylenes and azides was brought back into focus by Sharpless and others2 when they …

The concept of click chemistry represented by the formation of the 1, 2, 3-triazole core has
found wide application in drug discovery, particularly in the early discovery phases and the …

In the present perspective the advances and real possibilities of 1, 3-dipolar cycloadditions
as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and …

New 1, 3, 4-thiadiazole thioglycosides linked to substituted arylidine systems were
synthesized via glycosylation of the prepared 1, 3, 4-thiadiazole thiol compounds. Click …

Novel conjugates of substituted pyridine and carbohydrate moieties linked by 1, 2, 3-
triazoles were synthesized. The propargyl group was introduced by O-propargylation of …

Huisgen cycloaddition reaction has been originally utilized for the synthesis of 1, 2, 3-
triazoles regioisomers. In this review, its stereochemistry and also mechanistical features of …

Introduction: The HIV-1 gp120 envelope (Env) glycoprotein mediates attachment of virus to
human target cells that display requisite receptors, CD4 and co-receptor, generally CCR5 …

The copper-catalyzed azide-alkyne cycloaddition (CuAAC) is generally recognized as the
most striking example of “click reaction”. CuAAC fit so well into Sharpless' definition that it …

Abstract New 1, 2, 3-triazole glycosides and 1, 2, 4-thioglycosides incorporating a
substituted pyrimidinedione ring system were synthesized via click dipolar cycloaddition and …

In this study, we describe the synthesis of 1, 4-disustituted-1, 2, 3-triazolo-quinazoline
ribonucleosides or acyclonucleosides by means of 1, 3-dipolar cycloaddition between …