It has been estimated that up to one-third of the proteins encoded by the human genome
enter the endoplasmic reticulum (ER) as extended polypeptide chains where they undergo …

After acute kidney injury (AKI), renal function continues to deteriorate in some patients. In a
pro-inflammatory and profibrotic environment, the proximal tubules are subject to …

Background Sepsis-associated acute kidney injury (SA-AKI) is a common complication in
patients with sepsis, triggering high morbidity and mortality. Maresin-1 (MaR1) is a pro …

All cell types must maintain homeostasis under periods of stress. To prevent the catastrophic
effects of stress, all cell types also respond to stress by inducing protective pathways. Within …

Acute kidney injury (AKI) constitutes a prevalent clinical syndrome characterized by elevated
morbidity and mortality rates, emerging as a significant public health issue. This study …

GRP170 (Hyou1) is required for mouse embryonic development, and its ablation in kidney
nephrons leads to renal failure. Unlike most chaperones, GRP170 is the lone member of its …

GDF15, also known as MIC1, is a member of the TGF-beta superfamily. Previous studies
reported elevated serum levels of GDF15 in patients with kidney disorder, and its …

Transmembrane proteins have unique requirements to fold and integrate into the
endoplasmic reticulum (ER) membrane. Most notably, transmembrane proteins must fold in …

This study investigates the role of S100A9 in sepsis-associated AKI (SA-AKI) through the
lens of pyroptosis, a controlled form of cell death mediated by the gasdermin protein family …

The maintenance of fluid and electrolyte homeostasis by the kidney requires proper folding
and trafficking of ion channels and transporters in kidney epithelia. Each of these processes …