Congenital stationary night blindness: an analysis and update of genotype–phenotype correlations and pathogenic mechanisms
C Zeitz, AG Robson, I Audo - Progress in retinal and eye research, 2015 - Elsevier
Congenital stationary night blindness (CSNB) refers to a group of genetically and clinically
heterogeneous retinal disorders. Seventeen different genes with more than 360 different …
heterogeneous retinal disorders. Seventeen different genes with more than 360 different …
Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
ME Fini, SG Schwartz, X Gao, S Jeong, N Patel… - Progress in retinal and …, 2017 - Elsevier
Elevation of intraocular pressure (IOP) due to therapeutic use of glucocorticoids is called
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …
steroid-induced ocular hypertension (SIOH); this can lead to steroid-induced glaucoma …
Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR
Glycine is a major neurotransmitter involved in several fundamental neuronal processes.
The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine …
The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine …
Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex
GPR158 is an orphan G protein–coupled receptor (GPCR) highly expressed in the brain,
where it controls synapse formation and function. GPR158 has also been implicated in …
where it controls synapse formation and function. GPR158 has also been implicated in …
Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5
E Jeong, Y Kim, J Jeong, Y Cho - Nature communications, 2021 - nature.com
GPR158, a class C orphan GPCR, functions in cognition, stress-induced mood control, and
synaptic development. Among class C GPCRs, GPR158 is unique as it lacks a Venus flytrap …
synaptic development. Among class C GPCRs, GPR158 is unique as it lacks a Venus flytrap …
Glypicans and heparan sulfate in synaptic development, neural plasticity, and neurological disorders
K Kamimura, N Maeda - Frontiers in neural circuits, 2021 - frontiersin.org
Heparan sulfate proteoglycans (HSPGs) are components of the cell surface and
extracellular matrix, which bear long polysaccharides called heparan sulfate (HS) attached …
extracellular matrix, which bear long polysaccharides called heparan sulfate (HS) attached …
Neuronal G protein-gated K+ channels
H Luo… - American Journal of …, 2022 - journals.physiology.org
G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …
A massively parallel reporter assay library to screen short synthetic promoters in mammalian cells
Cellular responses to stimuli underpin discoveries in drug development, synthetic biology,
and general life sciences. We introduce a library comprising 6144 synthetic promoters, each …
and general life sciences. We introduce a library comprising 6144 synthetic promoters, each …
Subtype-dependent regulation of Gβγ signalling
G protein-coupled receptors (GPCRs) transmit information to the cell interior by transducing
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …
Shedding light on myopia by studying complete congenital stationary night blindness
C Zeitz, JE Roger, I Audo, C Michiels… - Progress in Retinal and …, 2023 - Elsevier
Myopia is the most common eye disorder, caused by heterogeneous genetic and
environmental factors. Rare progressive and stationary inherited retinal disorders are often …
environmental factors. Rare progressive and stationary inherited retinal disorders are often …