MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

MYB transcription factors are highly conserved from plants to vertebrates, indicating that
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …

CD8+ T cells that respond to chronic viral infections or cancer are characterized by the
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …

T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …

In certain human cancers, the expression of critical oncogenes is driven from large
regulatory elements, called super-enhancers, that recruit much of the cell's transcriptional …

Low-grade neuroepithelial tumors (LGNTs) are diverse CNS tumors presenting in children
and young adults, often with a history of epilepsy. While the genetic profiles of common …

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high …

T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of
hematopoietic progenitors primed toward T cell development, as result of a multistep …

Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a
leading cause of cancer death in the young. In the last decade, microarray and sequencing …

The transcription factor gene MYB was identified recently as an oncogene that is
rearranged/duplicated in some human leukemias. Here we describe a new mechanism of …