Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

Alzheimer´ s disease (AD) stands out as the most common chronic neurodegenerative
disorder. AD is characterized by progressive cognitive decline and memory loss, with …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways
that underlie its pathological progression across brain regions remain poorly understood …

While single-cell technologies have greatly advanced our comprehension of human brain
cell types and functions, studies including large numbers of donors and multiple brain …

APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds
ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non …

Microglia are central players in Alzheimer's disease pathology but analyzing microglial
states in human brain samples is challenging due to genetic diversity, postmortem delay and …

Identifying cell populations associated with risk variants is essential for uncovering cell-
specific mechanisms that drive disease development and progression. Integrating genome …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …

Background Recent trials of anti-amyloid-β (Aβ) monoclonal antibodies, including
lecanemab and donanemab, in early Alzheimer disease (AD) showed that these drugs have …