MHC class II epitope predictive algorithms
Major histocompatibility complex class II (MHC‐II) molecules sample peptides from the
extracellular space, allowing the immune system to detect the presence of foreign microbes …
extracellular space, allowing the immune system to detect the presence of foreign microbes …
Immunoinformatics: predicting peptide–MHC binding
Immunoinformatics is a discipline that applies methods of computer science to study and
model the immune system. A fundamental question addressed by immunoinformatics is how …
model the immune system. A fundamental question addressed by immunoinformatics is how …
NetMHCpan, a method for MHC class I binding prediction beyond humans
Binding of peptides to major histocompatibility complex (MHC) molecules is the single most
selective step in the recognition of pathogens by the cellular immune system. The human …
selective step in the recognition of pathogens by the cellular immune system. The human …
Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms
SG Hansen, JB Sacha, CM Hughes, JC Ford… - Science, 2013 - science.org
Introduction CD8+ T cell responses focus on a small fraction of total pathogen-encoded
peptides, which are similar among individuals with shared major histocompatibility complex …
peptides, which are similar among individuals with shared major histocompatibility complex …
T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection
M Buggert, J Tauriainen, T Yamamoto… - PLoS …, 2014 - journals.plos.org
CD8+ T cell exhaustion represents a major hallmark of chronic HIV infection. Two key
transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin …
transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin …
NetCTLpan: pan-specific MHC class I pathway epitope predictions
Reliable predictions of immunogenic peptides are essential in rational vaccine design and
can minimize the experimental effort needed to identify epitopes. In this work, we describe a …
can minimize the experimental effort needed to identify epitopes. In this work, we describe a …
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection
H Chen, ZM Ndhlovu, D Liu, LC Porter, JW Fang… - Nature …, 2012 - nature.com
The human leukocyte antigens HLA-B* 27 and HLA-B* 57 are associated with protection
against progression of disease that results from infection with human immunodeficiency …
against progression of disease that results from infection with human immunodeficiency …
The immune epitope database and analysis resource program 2003–2018: reflections and outlook
Abstract The Immune Epitope Database and Analysis Resource (IEDB) contains information
related to antibodies and T cells across an expansive scope of research fields (infectious …
related to antibodies and T cells across an expansive scope of research fields (infectious …
Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development
Z Staneková, E Varečková - Virology journal, 2010 - Springer
Influenza A viruses belong to the best studied viruses, however no effective prevention
against influenza infection has been developed. The emerging of still new escape variants …
against influenza infection has been developed. The emerging of still new escape variants …
Major histocompatibility complex class I binding predictions as a tool in epitope discovery
Over the last decade, in silico models of the major histocompatibility complex (MHC) class I
pathway have developed significantly. Before, peptide binding could only be reliably …
pathway have developed significantly. Before, peptide binding could only be reliably …