Genetic interactions identify combinations of genetic variants that im**e on phenotype.
With whole-genome sequence information available for thousands of individuals within a …

Background Most, if not all, organisms possess the ability to alter their phenotype in direct
response to changes in their environment, a phenomenon known as phenotypic plasticity …

INTRODUCTION Genetic interactions occur when mutations in different genes combine to
result in a phenotype that is different from expectation based on those of the individual …

In diploid species, genetic loci can show additive, dominance, and epistatic effects. To
characterize the contributions of these different types of genetic effects to heritable traits, we …

The contribution of genetic interactions involving three or more loci to complex traits is poorly
understood. These higher-order genetic interactions (HGIs) are difficult to detect in genetic …

The debate on the relative contributions of presumptive etiologic factors in the development
of obesity is becoming increasingly speculative, insular, and partisan. As the global …

Genetic interactions between mutations and standing polymorphisms can cause mutations
to show distinct phenotypic effects in different individuals. To characterize the genetic …

Symmetries are widespread invariances underscoring countless systems, including the
brain. A symmetry break occurs when the symmetry is present at one level of observation but …

Yeast flocculation is a community-building cell aggregation trait that is an important
mechanism of stress resistance and a useful phenotype for brewers; however, it is also a …

Statistical methodology has played a key role in scientific animal breeding. Approximately
one hundred years of statistical developments in animal breeding are reviewed. Some of the …