Cell–extracellular matrix mechanotransduction in 3D

A Saraswathibhatla, D Indana… - Nature Reviews Molecular …, 2023 - nature.com
Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Single-molecule localization microscopy

M Lelek, MT Gyparaki, G Beliu, F Schueder… - Nature reviews …, 2021 - nature.com
Single-molecule localization microscopy (SMLM) describes a family of powerful imaging
techniques that dramatically improve spatial resolution over standard, diffraction-limited …

Directed cell migration towards softer environments

A Isomursu, KY Park, J Hou, B Cheng, M Mathieu… - Nature materials, 2022 - nature.com
How cells sense tissue stiffness to guide cell migration is a fundamental question in
development, fibrosis and cancer. Although durotaxis—cell migration towards increasing …

Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration

Y Zhu, H Liang, X Liu, J Wu, C Yang, TM Wong… - Science …, 2021 - science.org
Proper immune responses are critical for successful biomaterial implantation. Here, four
scales of honeycomb-like TiO2 structures were custom made on titanium (Ti) substrates to …

Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction

W **e, X Wei, H Kang, H Jiang, Z Chu, Y Lin… - Advanced …, 2023 - Wiley Online Library
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

Super-resolution microscopy for structural cell biology

S Liu, P Hoess, J Ries - Annual Review of Biophysics, 2022 - annualreviews.org
Super-resolution microscopy techniques, and specifically single-molecule localization
microscopy (SMLM), are approaching nanometer resolution inside cells and thus have great …

The extracellular matrix in tumor progression and metastasis

JA Eble, S Niland - Clinical & experimental metastasis, 2019 - Springer
The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Visualizing and discovering cellular structures with super-resolution microscopy

YM Sigal, R Zhou, X Zhuang - Science, 2018 - science.org
Super-resolution microscopy has overcome a long-held resolution barrier—the diffraction
limit—in light microscopy and enabled visualization of previously invisible molecular details …

Cellulose biomaterials for tissue engineering

RJ Hickey, AE Pelling - Frontiers in bioengineering and …, 2019 - frontiersin.org
In this review, we highlight the importance of nanostructure of cellulose-based biomaterials
to allow cellular adhesion, the contribution of nanostructure to macroscale mechanical …

The cytoskeleton in phagocytosis and macropinocytosis

S Mylvaganam, SA Freeman, S Grinstein - Current Biology, 2021 - cell.com
Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …