RNA interference-mediated antiviral defense in insects

DB Gammon, CC Mello - Current opinion in insect science, 2015 - Elsevier
Highlights•Insect RNA interference (RNAi) pathways detect and restrict viruses.•Dicer-2
detects diverse viral dsRNA signatures and initiates the RNAi pathway.•RNAi may play a …

Viral delivery of dsRNA for control of insect agricultural pests and vectors of human disease: prospects and challenges

A Kolliopoulou, CNT Taning, G Smagghe… - Frontiers in …, 2017 - frontiersin.org
RNAi is applied as a new and safe method for pest control in agriculture but efficiency and
specificity of delivery of dsRNA trigger remains a critical issue. Various agents have been …

Virus replication in the honey bee parasite, Varroa destructor

JE Damayo, RC McKee, G Buchmann… - Journal of …, 2023 - journals.asm.org
The ectoparasitic mite Varroa destructor is the leading threat to the health of Western honey
bees (Apis mellifera) primarily through its action as a vector of viruses. However, it is unclear …

Emerging strategies for RNA interference (RNAi) applications in insects

RS Nandety, YW Kuo, S Nouri, BW Falk - Bioengineered, 2015 - Taylor & Francis
RNA interference (RNAi) in insects is a gene regulatory process that also plays a vital role in
the maintenance and in the regulation of host defenses against invading viruses. Small …

Mosquito and Drosophila entomobirnaviruses suppress dsRNA- and siRNA-induced RNAi

KWR van Cleef, JT van Mierlo, P Miesen… - Nucleic acids …, 2014 - academic.oup.com
RNA interference (RNAi) is a crucial antiviral defense mechanism in insects, including the
major mosquito species that transmit important human viruses. To counteract the potent …

Diverse array of new viral sequences identified in worldwide populations of the Asian citrus psyllid (Diaphorina citri) using viral metagenomics

S Nouri, N Salem, JC Nigg, BW Falk - Journal of virology, 2016 - journals.asm.org
ABSTRACT The Asian citrus psyllid, Diaphorina citri, is the natural vector of the causal agent
of Huanglongbing (HLB), or citrus greening disease. Together; HLB and D. citri represent a …

Viral small-RNA analysis of Bombyx mori larval midgut during persistent and pathogenic cytoplasmic polyhedrosis virus infection

A Zografidis, F Van Nieuwerburgh… - Journal of …, 2015 - journals.asm.org
The lepidopteran innate immune response against RNA viruses remains poorly understood,
while in other insects several studies have highlighted an essential role for the exo-RNAi …

Extracellular vesicles spread the RNA interference signal of Tribolium castaneum TcA cells

L Mingels, N Wynant, D Santos, P Peeters… - Insect Biochemistry and …, 2020 - Elsevier
The potential utility of RNA interference (RNAi) to control insect pests and viral infections
depends largely on the target organism's ability to systemically spread the RNAi response …

Profile and functional analysis of small RNAs derived from Aspergillus fumigatus infected with double-stranded RNA mycoviruses

S Özkan, I Mohorianu, P Xu, T Dalmay, RHA Coutts - BMC genomics, 2017 - Springer
Background Mycoviruses are viruses that naturally infect and replicate in fungi. Aspergillus
fumigatus, an opportunistic pathogen causing fungal lung diseases in humans and animals …

The Use of Engineered Plant Viruses in a Trans-Kingdom Silencing Strategy Against Their Insect Vectors

A Kolliopoulou, D Kontogiannatos… - Frontiers in Plant …, 2020 - frontiersin.org
Plants, plant viruses, and their vectors are co-evolving actors that co-exist and interact in
nature. Insects are the most important vectors of plant viruses, serving as both carriers and …