Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Alzheimer's disease (AD) is one of the most common forms of dementia. Despite a wealth of
knowledge on the molecular mechanisms involved in AD, current treatments have mainly …

According to the β-amyloid (Aβ) hypothesis of Alzheimer's disease (AD), brain Aβ
accumulation is the primary cascade event leading to cognitive deficit and dementia …

In the last few years, increased emphasis has been devoted to understanding the
contribution of mitochondria-associated endoplasmic reticulum (ER) membranes (MAM) to …

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by amyloid
plaques in patients' brain tissue. The plaques are mainly made of β-amyloid peptides and …

Introduction: The amyloid hypothesis of Alzheimer's disease (AD) states that brain
accumulation of amyloid-β (Aβ) oligomers and soluble aggregates represents the major …

Alzheimer's disease (AD) is an irreversible, age-related progressive neurological disorder,
and the most common type of dementia in aged people. Neuropathological lesions of AD …

Amyloid and tau aggregation are implicated in manifold neurodegenerative diseases and
serve as two signature pathological hallmarks in Alzheimer's disease (AD). Though aging is …

Over the past 30 years, the majority of (pre) clinical efforts to find an effective therapy for
Alzheimer's disease (AD) focused on clearing the β-amyloid peptide (Aβ) from the brain …

Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …