The human nervous system is a remarkably complex physiological network that is inherently
challenging to study because of obstacles to acquiring primary samples. Animal models …

Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …

Plastics have been part of our ecosystem for about a century and their degradation by
different environmental factors produce secondary microplastics (MPs). To date, the impact …

Current brain spheroids or organoids derived from human induced pluripotent stem cells
(hiPSCs) still lack a microglia component, the resident immune cells in the brain. The …

In vitro models of the human blood–brain barrier (BBB) are increasingly used to develop
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …

Human cerebral organoids derived from induced pluripotent stem cells (iPSCs) provide
novel tools for recapitulating the cytoarchitecture of human brain and for studying biological …

Brain organoids are self‐organized, three‐dimensional (3D) aggregates derived from
pluripotent stem cells that have cell types and cellular architectures resembling those of the …

The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs
development pipeline by mimicking the physiological environment and functions of human …

Abstract 3D laboratory tissue cultures have emerged as an alternative to traditional 2D
culture systems that do not recapitulate native cell behavior. The discrepancy between in …

Neurodegenerative diseases are a group of disorders characterized by progressive
degeneration of the structural and functional integrity of the central and peripheral nervous …