Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

Cellular redox homeostasis is precisely balanced by generation and elimination of reactive
oxygen species (ROS). ROS are not only capable of causing oxidation of proteins, lipids and …

The mitochondrial unfolded protein response (UPRmt) is essential to safeguard
mitochondria from proteotoxic damage by activating a dedicated transcriptional response in …

Amyloid-like aggregates of the microtubule-associated protein Tau are associated with
several neurodegenerative disorders including Alzheimer's disease. The existence of …

While acetylated, RNA-binding-deficient TDP-43 reversibly phase separates within nuclei
into complex droplets (anisosomes) comprised of TDP-43-containing liquid outer shells and …

Biomolecules are in constant motion. To understand how they function, and why
malfunctions can cause disease, it is necessary to describe their three-dimensional …

Stresses such as heat shock trigger the formation of protein aggregates and the induction of
a disaggregation system composed of molecular chaperones. Recent work reveals that …

Understanding the mechanisms that drive TDP-43 pathology is integral to combating
amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other …

Eukaryotic cells are equipped with an intricate proteostasis network (PN), comprising nearly
3,000 components dedicated to preserving proteome integrity and sustaining protein …

Molecular photoswitches are potent tools to construct dynamic functional systems and
responsive materials that can be controlled in a non-invasive manner. As P-type …