Activity of N-phenylbenzamide analogs against the neglected disease pathogen, Schistosoma mansoni

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[HTML][HTML] EDBD—3,6-Epidioxy-1,10-Bisaboladiene—An Endoperoxide Sesquiterpene Obtained from Drimys brasiliensis (Winteraceae) Exhibited Potent Preclinical Efficacy …

E Umehara, TR Teixeira, RA Cajás, MC Amaro… - Antibiotics, 2024 - mdpi.com
Schistosomiasis, a neglected tropical disease impacting over 250 million individuals
globally, remains a major public health challenge due to its prevalence and significant …
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Chemoselective C–H Hydroxylation and Borylation of N-Phenylbenzamides using BBr3

W Chen, J **a, J Huang, L Zhou, G Wu - Organic Letters, 2024 - ACS Publications
A novel metal-free chemoselective C–H hydroxylation and borylation of N-
phenylbenzamides using BBr3 is described. The protocol generates the corresponding …
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Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease

JA Nunes, PF da Silva Santos-Júnior… - European Journal of …, 2025 - Elsevier
Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei (T. brucei) urgently demand
innovative drug development due to their impact on public health worldwide. Their cysteine …
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Β-Lapachone-Dendrimer inclusion complex: Physicochemical characterization and its application against different evolutionary phases of Schistosoma mansoni

DSC Marques, CA da Cruz Amorim… - Journal of Drug Delivery …, 2025 - Elsevier
Abstract β-lapachone, derived from lapachol, has various biological activities. It induces
death in both young and adult Schistosoma mansoni worms, the cause of schistosomiasis …
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Therapeutic potential of hydantoin and thiohydantoin compounds against Schistosoma mansoni: An integrated in vitro, DNA, ultrastructural, and ADMET in silico …

AS de Almeida Júnior, MMFV Leal… - Molecular and …, 2024 - Elsevier
The study aimed to conduct in vitro biological assessments of hydantoin and thiohydantoin
compounds against mature Schistosoma mansoni worms, evaluate their cytotoxic effects …
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[HTML][HTML] Structure activity relationships of antischistosomal N-phenylbenzamides by incorporation of electron-withdrawing functionalities

AM Dawoodjee, J Sichinga, H Banda, S Mbaya… - Results in …, 2024 - Elsevier
For the adult Schistosoma mansoni flatworm pathogen, we report further structure activity
relationships (SAR) of 19 N-phenylbenzamide analogs. Our previous SAR studies, designed …
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AM Dawoodjee, J Sichinga, H Banda, S Mbaya… - researchgate.net
For the adult Schistosoma mansoni flatworm pathogen, we report further structure activity
relationships (SAR) of 19 N-phenylbenzamide analogs. Our previous SAR studies, designed …
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Structure activity relationships of antischistosomal N-phenylbenzamides by incorporation of electron-withdrawing functionalities

PM Cheuka, AM Dawoodjee, J Sichinga… - Available at SSRN … - papers.ssrn.com
For the adult Schistosoma mansoni flatworm pathogen, we report further structure activity
relationships (SAR) of 19 N-phenylbenzamide analogs. Our previous SAR studies, designed …
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[PDF][PDF] Antischistosomal structure-activity relationships of nitrated n-phenyl benzamide derivatives.

J Sichinga - 2023 - dspace.unza.zm
Schistosomiasis is a chronic parasitic disease caused by blood-dwelling trematodes of the
genus Schistosoma. It ranks second on a list of neglected tropical parasitic diseases …
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