Bacterial chromate reductase, a potential enzyme for bioremediation of hexavalent chromium: a review
Hexavalent chromium is mobile, highly toxic and considered as a priority environmental
pollutant. Chromate reductases, found in chromium resistant bacteria are known to catalyse …
pollutant. Chromate reductases, found in chromium resistant bacteria are known to catalyse …
Progress and problems with the use of suicide genes for targeted cancer therapy
Among various gene therapy methods for cancer, suicide gene therapy attracts a special
attention because it allows selective conversion of non-toxic compounds into cytotoxic drugs …
attention because it allows selective conversion of non-toxic compounds into cytotoxic drugs …
A comparative review towards potential of microbial cells for heavy metal removal with emphasis on biosorption and bioaccumulation
The threat of heavy metal pollution to environmental health is getting worldwide attention
due to their persistence and non-biodegradable nature. Ineffectiveness of various …
due to their persistence and non-biodegradable nature. Ineffectiveness of various …
Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302
F Meng, JW Evans, D Bhupathi, M Banica, L Lan… - Molecular cancer …, 2012 - AACR
Abstract TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-
isophosphoramide mustard currently undergoing clinical evaluation. Here, we describe …
isophosphoramide mustard currently undergoing clinical evaluation. Here, we describe …
Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility
This review examines the vast catalytic and therapeutic potential offered by type I (ie oxygen-
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …
In vivo imaging and detection of nitroreductase in zebrafish by a new near-infrared fluorescence off–on probe
Z Li, X He, Z Wang, R Yang, W Shi, H Ma - Biosensors and Bioelectronics, 2015 - Elsevier
A new near-infrared fluorescence off–on probe is developed and applied to fluorescence
imaging of nitroreductase in zebrafish in vivo. The probe is readily prepared by connecting 4 …
imaging of nitroreductase in zebrafish in vivo. The probe is readily prepared by connecting 4 …
Revealing unexplored sequence-function space using sequence similarity networks
The rapidly expanding number of protein sequences found in public databases can improve
our understanding of how protein functions evolve. However, our current knowledge of …
our understanding of how protein functions evolve. However, our current knowledge of …
Enzyme/prodrug systems for cancer gene therapy
The use of enzyme/prodrug system has gained attention because it could help improve the
efficacy and safety of conventional cancer chemotherapies. In this approach, cancer cells …
efficacy and safety of conventional cancer chemotherapies. In this approach, cancer cells …
Engineering a multifunctional nitroreductase for improved activation of prodrugs and PET probes for cancer gene therapy
Gene-directed enzyme-prodrug therapy (GDEPT) is a promising anti-cancer strategy.
However, inadequate prodrugs, inefficient prodrug activation, and a lack of non-invasive …
However, inadequate prodrugs, inefficient prodrug activation, and a lack of non-invasive …
Escherichia coli NemA Is an Efficient Chromate Reductase That Can Be Biologically Immobilized to Provide a Cell Free System for Remediation of Hexavalent …
Hexavalent chromium is a serious and widespread environmental pollutant. Although many
bacteria have been identified that can transform highly water-soluble and toxic Cr (VI) to …
bacteria have been identified that can transform highly water-soluble and toxic Cr (VI) to …