The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles
E Fröhlich - International journal of nanomedicine, 2012 - Taylor & Francis
Many types of nanoparticles (NPs) are tested for use in medical products, particularly in
imaging and gene and drug delivery. For these applications, cellular uptake is usually a …
imaging and gene and drug delivery. For these applications, cellular uptake is usually a …
The great escape: how cationic polyplexes overcome the endosomal barrier
The targeted and efficiency-oriented delivery of (therapeutic) nucleic acids raises hope for
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …
successful gene therapy, ie, for the local and individual treatment of acquired and inherited …
Dendrimer toxicity: Let's meet the challenge
Dendrimers are well-defined, versatile polymeric architecture with properties resembling
biomolecules. Dendritic polymers emerged as outstanding carrier in modern medicine …
biomolecules. Dendritic polymers emerged as outstanding carrier in modern medicine …
Nanoparticle: An overview of preparation and characterization
In recent years, there has been an exponential interest in the development of novel drug
delivery systems using nanoparticles. Nanoparticles can offer significant advantages over …
delivery systems using nanoparticles. Nanoparticles can offer significant advantages over …
PEGylated PAMAM dendrimers: Enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery
Abstract Poly (amidoamine) dendrimers (PAMAM) are well-defined, highly branched,
nanoscale macromolecules with numerous active amine groups on the surface. PAMAM …
nanoscale macromolecules with numerous active amine groups on the surface. PAMAM …
Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability
S Hong, PR Leroueil, EK Janus, JL Peters… - Bioconjugate …, 2006 - ACS Publications
Interactions of polycationic polymers with supported 1, 2-dimyristoyl-sn-glycero-3-
phosphocholine (DMPC) lipid bilayers and live cell membranes (KB and Rat2) have been …
phosphocholine (DMPC) lipid bilayers and live cell membranes (KB and Rat2) have been …
Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers
Nanoparticles with widely varying physical properties and origins (spherical versus irregular,
synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus …
synthetic versus biological, organic versus inorganic, flexible versus rigid, small versus …
Interaction of poly (amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport
S Hong, AU Bielinska, A Mecke, B Keszler… - Bioconjugate …, 2004 - ACS Publications
We have investigated poly (amidoamine)(PAMAM) dendrimer interactions with supported 1,
2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayers and KB and Rat2 cell …
2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayers and KB and Rat2 cell …
Nanotechnology safety concerns revisited
ST Stern, SE McNeil - Toxicological sciences, 2008 - academic.oup.com
Nanotechnology is an emerging science involving manipulation of matter at the nanometer
scale. Due to concerns over nanomaterial risks, there has been a dramatic increase in …
scale. Due to concerns over nanomaterial risks, there has been a dramatic increase in …
Therapeutic and diagnostic applications of dendrimers for cancer treatment
JB Wolinsky, MW Grinstaff - Advanced drug delivery reviews, 2008 - Elsevier
Dendrimers are prepared with a level of control not attainable with most linear polymers,
leading to nearly monodisperse, globular macromolecules with a large number of peripheral …
leading to nearly monodisperse, globular macromolecules with a large number of peripheral …