Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial
stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with …

BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells …

Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …

Aging men display reduced reproductive health; however, testis aging is poorly understood
at the molecular and genomic levels. Here, we utilized single-cell RNA-seq to profile over …

Spermatogenesis is a highly regulated process that produces sperm to transmit genetic
information to the next generation. Although extensively studied in mice, our current …

STUDY QUESTION What clinical practices, patient management strategies and
experimental methods are currently being used to preserve and restore the fertility of …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

BACKGROUND Germ cell depletion caused by chemical or physical toxicity, disease or
genetic predisposition can occur at any age. Although semen cryopreservation is the first …

Abstract Three-dimensional (3D) organoids can serve as an in vitro platform to study cell–
cell interactions, tissue development, and toxicology. Development of organoids with tissue …

The majority of children, adolescents, and young adults diagnosed with cancer today will
become long-term survivors. The threat to fertility that cancer treatments pose to young …