Cell–extracellular matrix mechanotransduction in 3D

A Saraswathibhatla, D Indana… - Nature Reviews Molecular …, 2023 - nature.com
Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Chemical strategies to engineer hydrogels for cell culture

J Lou, DJ Mooney - Nature Reviews Chemistry, 2022 - nature.com
Two-dimensional and three-dimensional cell culture systems are widely used for biological
studies, and are the basis of the organoid, tissue engineering and organ-on-chip research …

Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

H Cao, L Duan, Y Zhang, J Cao, K Zhang - Signal transduction and …, 2021 - nature.com
Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Engineering the multiscale complexity of vascular networks

C O'Connor, E Brady, Y Zheng, E Moore… - Nature Reviews …, 2022 - nature.com
The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …

Dynamic and reconfigurable materials from reversible network interactions

MJ Webber, MW Tibbitt - Nature Reviews Materials, 2022 - nature.com
Polymer materials provide solutions to some of the most pressing environmental,
manufacturing and health-care challenges. Traditional thermoplastic and thermoset …

Stimuli-responsive dynamic hydrogels: design, properties and tissue engineering applications

S Amirthalingam, AK Rajendran, YG Moon… - Materials …, 2023 - pubs.rsc.org
The field of tissue engineering and regenerative medicine has been evolving at a rapid pace
with numerous novel and interesting biomaterials being reported. Hydrogels have come a …

Tunable hydrogel viscoelasticity modulates human neural maturation

JG Roth, MS Huang, RS Navarro, JT Akram… - Science …, 2023 - science.org
Human-induced pluripotent stem cells (hiPSCs) have emerged as a promising in vitro model
system for studying neurodevelopment. However, current models remain limited in their …

Viscoelastic cell microenvironment: hydrogel‐based strategy for recapitulating dynamic ECM mechanics

Y Ma, T Han, Q Yang, J Wang, B Feng… - Advanced Functional …, 2021 - Wiley Online Library
The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Mechanics of 3D cell–hydrogel interactions: experiments, models, and mechanisms

FJ Vernerey, S Lalitha Sridhar, A Muralidharan… - Chemical …, 2021 - ACS Publications
Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

3D printing of microgel scaffolds with tunable void fraction to promote cell infiltration

AJ Seymour, S Shin… - Advanced healthcare …, 2021 - Wiley Online Library
Granular, microgel‐based materials have garnered interest as promising tissue engineering
scaffolds due to their inherent porosity, which can promote cell infiltration. Adapting these …