In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …

Spatial organization is an inherent property of the vertebrate genome to accommodate the
roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically …

Here, we provide an update of our review on homeobox genes that we wrote together with
Walter Gehring in 1994. Since then, comprehensive surveys of homeobox genes have …

How tissue regeneration programs are triggered by injury has received limited research
attention. Here we investigate the existence of enhancer regulatory elements that are …

Chromosome conformation is an important feature of metazoan gene regulation,; however,
enhancer–promoter contact remodeling during cellular differentiation remains poorly …

Collinear regulation of Hox genes in space and time has been an outstanding question ever
since the initial work of Ed Lewis in 1978. Here we discuss recent advances in our …

Long-range gene regulation involves physical proximity between enhancers and promoters
to generate precise patterns of gene expression in space and time. However, in some cases …

The mammalian HoxD cluster lies between two topologically associating domains (TADs)
matching distinct enhancer-rich regulatory landscapes. During limb development, the …

Enhancers are distally located genomic cis-regulatory elements that integrate
spatiotemporal cues to coordinate gene expression in a tissue-specific manner during …