[HTML][HTML] Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function

J Wen, SK Satyanarayanan, A Li, L Yan, Z Zhao… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's disease (AD) and other forms of dementia represent major public health
challenges but effective therapeutic options are limited. Pathological brain aging is …

Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption

BJ Klievik, AD Tyrrell, CT Chen, RP Bazinet - Pharmacology & Therapeutics, 2023 - Elsevier
Abstract Docosahexaenoic acid (DHA, 22: 6n-3) accretion in brain phospholipids is critical
for maintaining the structural fluidity that permits proper assembly of protein complexes for …

Nutrition in Alzheimer's disease: A review of an underappreciated pathophysiological mechanism

J Jiang, H Shi, S Jiang, A Wang, X Zou, Y Wang… - Science China Life …, 2023 - Springer
Alzheimer's disease (AD) is the leading cause of dementia in older individuals and is an
escalating challenge to global public health. Pharmacy therapy of AD is one of the well …

The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer's disease

YG Wu, LJ Song, LJ Yin, JJ Yin, Q Wang… - Neural Regeneration …, 2023 - journals.lww.com
Microglia are resident immune cells in the central nervous system. During the pathogenesis
of Alzheimer's disease, stimulatory factors continuously act on the microglia causing …

The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: A systematic review and dose–response meta-analysis

SW Suh, E Lim, SY Burm, H Lee, JB Bae, JW Han… - BMC medicine, 2024 - Springer
Background Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been suggested as a
cognitive enhancing agent, though their effect is doubtful. We aimed to examine the effect of …

[HTML][HTML] Associations of erythrocyte omega-3 fatty acids with cognition, brain imaging and biomarkers in the Alzheimer's disease neuroimaging initiative: Cross …

L Rouch, KV Giudici, C Cantet, S Guyonnet… - The American journal of …, 2022 - Elsevier
Background The association between omega-3 (ω-3) PUFAs and cognition, brain imaging
and biomarkers is still not fully established. Objectives The aim was to analyze the cross …

Potential Neuroprotective Effects of Dietary Omega-3 Fatty Acids on Stress in Alzheimer's Disease

KB Hartnett, BJ Ferguson, PM Hecht, LE Schuster… - Biomolecules, 2023 - mdpi.com
Background: A large number of individual potentially modifiable factors are associated with
risk for Alzheimer's disease (AD). However, less is known about the interactions between the …

[HTML][HTML] Combined drug triads for synergic neuroprotection in retinal degeneration

V Maneu, P Lax, AMG De Diego, N Cuenca… - Biomedicine & …, 2022 - Elsevier
This review focuses on retina degeneration occurring during glaucoma, age-related macular
degeneration (AMD), diabetic retinopathy (DR), and retinitis pigmentosa (RP), and on the …

Fundamentals of membrane lipid replacement: A natural medicine approach to repairing cellular membranes and reducing fatigue, pain, and other symptoms while …

GL Nicolson, G Ferreira de Mattos, M Ash, R Settineri… - Membranes, 2021 - mdpi.com
Membrane Lipid Replacement (MLR) uses natural membrane lipid supplements to safely
replace damaged, oxidized lipids in membranes in order to restore membrane function …

Cognitive Benefits of Folic Acid, Docosahexaenoic Acid, and a Combination of Both Nutrients in Mild Cognitive Impairment: Possible Alterations through Mitochondrial …

M Li, T Li, T Yang, L Huang, J Zhao, H Liu, Y Chen… - Gerontology, 2024 - karger.com
Introduction: It is uncertain whether folic acid (FA) combined with docosahexaenoic acid
(DHA) could improve cognitive performance. This study evaluated the effects of a 12-month …