Copper is too redox active to exist in an unbound form in the cell without causing oxidative
damage: an upper limit of 10-18 M for the free concentration of Cu (II) in unstressed cells has …

Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Protein misfolding and formation of β-sheet-rich amyloid fibrils or aggregates is related to
cellular toxicity and decay in various human disorders including Alzheimer's and Parkinson's …

Polyamines are polycations that interact with negatively charged molecules such as DNA,
RNA and proteins. They play multiple roles in cell growth, survival and proliferation …

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

In Parkinsons disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra
pars compacta is associated with Lewy bodies arising from the accumulation of alpha …

Biomolecular condensates present in cells can fundamentally affect the aggregation of
amyloidogenic proteins and play a role in the regulation of this process. While liquid-liquid …

The intrinsically disordered protein α-synuclein plays a key role in the pathogenesis of
Parkinson's disease (PD). We show here that the native state of α-synuclein consists of a …

Macroautophagy is a major intracellular degradation process recognized as playing a
central role in cell survival and longevity. This multistep process is extensively regulated at …