Small RNAs and extracellular vesicles: New mechanisms of cross-species communication and innovative tools for disease control
Small RNA (sRNA)-mediated RNA interference (RNAi) is a conserved regulatory
mechanism for gene expression throughout the domain Eukarya. Recent studies have …
mechanism for gene expression throughout the domain Eukarya. Recent studies have …
[HTML][HTML] Helminth parasites and immune regulation
PH Gazzinelli-Guimaraes, TB Nutman - F1000Research, 2018 - ncbi.nlm.nih.gov
Helminth parasites are complex metazoans that belong to different taxonomic families but
that collectively share the capacity to downregulate the host immune response directed …
that collectively share the capacity to downregulate the host immune response directed …
[HTML][HTML] The protein and microRNA cargo of extracellular vesicles from parasitic helminths–current status and research priorities
J Sotillo, MW Robinson, MJ Kimber, M Cucher… - International journal for …, 2020 - Elsevier
Helminth parasites have a remarkable ability to persist within their mammalian hosts, which
is largely due to their secretion of molecules with immunomodulatory properties. Although …
is largely due to their secretion of molecules with immunomodulatory properties. Although …
Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities
Parasitic helminths have coevolved with humans over millennia, intricately refining and
develo** an array of mechanisms to suppress or skew the host's immune system, thereby …
develo** an array of mechanisms to suppress or skew the host's immune system, thereby …
Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism
Schistosome infection persists for decades. Parasites are in close contact with host
peripheral blood immune cells, yet little is known about the regulatory interactions between …
peripheral blood immune cells, yet little is known about the regulatory interactions between …
Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre-and post-harvest plant protection
Highlights•Small RNAs can transfer from pathogens or parasites into their interacting
hosts.•Plant and animal hosts can deliver small RNAs into interacting pathogens and …
hosts.•Plant and animal hosts can deliver small RNAs into interacting pathogens and …
Tomato yellow leaf curl virus intergenic siRNAs target a host long noncoding RNA to modulate disease symptoms
Tomato yellow leaf curl virus (TYLCV) and its related begomoviruses cause fast-spreading
diseases in tomato worldwide. How this virus induces diseases remains largely unclear …
diseases in tomato worldwide. How this virus induces diseases remains largely unclear …
Profiling extracellular vesicle release by the filarial nematode Brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin
The filarial nematode Brugia malayi is an etiological agent of Lymphatic Filariasis. The
capability of B. malayi and other parasitic nematodes to modulate host biology is recognized …
capability of B. malayi and other parasitic nematodes to modulate host biology is recognized …
Extracellular vesicles from Echinococcus granulosus larval stage: Isolation, characterization and uptake by dendritic cells
The secretion of extracellular vesicles (EVs) in helminth parasites is a constitutive
mechanism that promotes survival by improving their colonization and adaptation in the host …
mechanism that promotes survival by improving their colonization and adaptation in the host …
The importance of extracellular vesicle purification for downstream analysis: A comparison of differential centrifugation and size exclusion chromatography for …
CN Davis, H Phillips, JJ Tomes, MT Swain… - PLoS neglected …, 2019 - journals.plos.org
Background Robust protocols for the isolation of extracellular vesicles (EVs) from the rest of
their excretory-secretory products are necessary for downstream studies and application …
their excretory-secretory products are necessary for downstream studies and application …