Glucocorticoids (GCs) are steroids secreted by the adrenal cortex under the hypothalamic-
pituitary-adrenal axis control, one of the major neuro-endocrine systems of the organism …

Adipose tissue signals to brain, liver, and muscles to control whole body metabolism through
secreted lipid and protein factors as well as neurotransmission, but the mechanisms …

Beige and brown adipocytes generate heat in response to reductions in ambient
temperature. When warmed, both beige and brown adipocytes exhibit morphological" …

Glucocorticoids regulate a remarkable variety of essential functions, including development,
immunomodulation, maintenance of circadian rhythm and the response to stress …

Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and
in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that …

The available evidence suggests a complex relationship between diabetes and cancer.
Epidemiological data suggest a positive correlation, however, in certain types of cancer, a …

Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during
stress, such as fasting and starvation, in order to maintain plasma glucose levels. Excess …

Glucocorticoids (GCs) are hormones that aid the body under stress by regulating glucose
and free fatty acids. GCs maintain energy homeostasis in multiple tissues, including those in …

Endogenous circadian clocks adapt an organism's physiology and behavior to predictable
changes in the environment as a consequence of the Earth's rotation around its axis. In …

Ethnopharmacological relevance Berberine (BBR), extracted from the traditional medicinal
plant Coptis chinensis Franch., has been widely used for the treatment of type 2 diabetes …