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An inflammation-centric view of neurological disease: beyond the neuron
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
The concept of multiple macrophage activation states is not new. However, extending this
idea to resident tissue macrophages, like microglia, has gained increased interest in recent …
idea to resident tissue macrophages, like microglia, has gained increased interest in recent …
Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …
excessive and chronic inflammatory responses can lead to deleterious effects involving …
The role of inflammation in perinatal brain injury
Inflammation is increasingly recognized as being a critical contributor to both normal
development and injury outcome in the immature brain. The focus of this Review is to …
development and injury outcome in the immature brain. The focus of this Review is to …
[HTML][HTML] Palmitoylethanolamide: A natural compound for health management
P Clayton, M Hill, N Bogoda, S Subah… - International journal of …, 2021 - mdpi.com
All nations which have undergone a nutrition transition have experienced increased
frequency and falling latency of chronic degenerative diseases, which are largely driven by …
frequency and falling latency of chronic degenerative diseases, which are largely driven by …
Mast cells in neuroinflammation and brain disorders
It is well recognized that neuroinflammation is involved in the pathogenesis of various
neurodegenerative diseases. Microglia and astrocytes are major pathogenic components …
neurodegenerative diseases. Microglia and astrocytes are major pathogenic components …
Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders
Autism spectrum disorders (ASDs) affect as many as 1 in 45 children and are characterized
by deficits in sociability and communication, as well as stereotypic movements. Many …
by deficits in sociability and communication, as well as stereotypic movements. Many …
Immune response in neurological pathology: emerging role of central and peripheral immune crosstalk
Neuroinflammation is a key component of neurological disorders and is an important
therapeutic target; however, immunotherapies have been largely unsuccessful. In cases …
therapeutic target; however, immunotherapies have been largely unsuccessful. In cases …
Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice
Emerging evidence suggests that peripheral immune cells contribute to Alzheimer's disease
(AD) neuropathogenesis. Among these, mast cells are known for their functions in allergic …
(AD) neuropathogenesis. Among these, mast cells are known for their functions in allergic …
Mast cells, glia and neuroinflammation: partners in crime?
Glia and microglia in particular elaborate pro‐inflammatory molecules that play key roles in
central nervous system (CNS) disorders from neuropathic pain and epilepsy to …
central nervous system (CNS) disorders from neuropathic pain and epilepsy to …