The major hallmark of cellular senescence is an irreversible cell cycle arrest and thus it is a
potent tumor suppressor mechanism. Genotoxic insults, eg oxidative stress, are important …

The fundamental mechanisms that control and regulate biological organisms exhibit a
surprising level of complexity. Oscillators are perhaps the simplest motifs that produce time …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …

Peptidoglycan recognition proteins (PGRPs) are key regulators of insect immune responses.
In addition to recognition PGRPs, which activate the Toll and Imd pathways, the Drosophila …

Living organisms are constantly exposed to DNA damage, and optimal repair is therefore
crucial. A characteristic hallmark of the response is the formation of sub-compartments …

The control of proteins by a transcription factor with periodically varying concentration
exhibits intriguing dynamical behaviour. Even though it is accepted that transcription factors …

Transient receptor potential vanilloid subfamily member 6 (TRPV6) is a highly selective
calcium channel that has been considered as a part of store-operated calcium entry (SOCE) …

NF-κB signaling plays a pivotal role in control of the inflammatory response. We investigated
how the dynamics and function of NF-κB were affected by temperature within the …

Arabidopsis plants store part of the carbon fixed by photosynthesis as starch to sustain
growth at night. Two competing hypotheses have been proposed to explain this diel starch …

Proneural transcription factors (TFs) such as Ascl1 function as master regulators of
neurogenesis in vertebrates, being both necessary and sufficient for the activation of a full …