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[HTML][HTML] Challenges of CRISPR/Cas-Based Cell Therapy for Type 1 Diabetes: How Not to Engineer a “Trojan Horse”
Type 1 diabetes mellitus (T1D) is an autoimmune disease caused by the destruction of
insulin-producing β-cells in the pancreas by cytotoxic T-cells. To date, there are no drugs …
insulin-producing β-cells in the pancreas by cytotoxic T-cells. To date, there are no drugs …
Exploring cutting-edge approaches in diabetes care: from nanotechnology to personalized therapeutics
Diabetes mellitus (DM) is a persistent condition characterized by high levels of glucose in
the blood due to irregularities in the secretion of insulin, its action, or both. The disease was …
the blood due to irregularities in the secretion of insulin, its action, or both. The disease was …
In vitro generation of transplantable insulin-producing cells from canine adipose-derived mesenchymal stem cells
Canine mesenchymal stem cells (cMSCs) have potential applications for regenerative
therapy, including the generation of insulin-producing cells (IPCs) for studying and treating …
therapy, including the generation of insulin-producing cells (IPCs) for studying and treating …
Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy
Aims Generation of mature β-cells from MSCs has been a challenge in the field of stem cell
therapy of diabetes. Adipose tissue-derived mesenchymal stem cells (Ad-MSCs) have made …
therapy of diabetes. Adipose tissue-derived mesenchymal stem cells (Ad-MSCs) have made …
The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy
X Wang, M Gao, Y Wang, Y Zhang - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by
high blood glucose levels either due to an absolute deficiency of insulin secretion or an …
high blood glucose levels either due to an absolute deficiency of insulin secretion or an …
Nanoparticle-mediated CRISPR/dCas9a activation of multiple transcription factors to engineer insulin-producing cells
Insulin may help to control blood glucose levels in diabetes; however, the long-term release
of insulin is important for therapy. In this work, four guide RNAs (gRNA) for factors that …
of insulin is important for therapy. In this work, four guide RNAs (gRNA) for factors that …
Identification of ferroptosis‐related genes in type 2 diabetes mellitus based on machine learning
S Wang, Y Lu, T Chi, Y Zhang, Y Zhao… - Immunity …, 2023 - Wiley Online Library
Background Type 2 diabetes mellitus (T2DM), which has a high incidence and several
harmful consequences, poses a severe danger to human health. Research on the function …
harmful consequences, poses a severe danger to human health. Research on the function …
Recent advances in the generation of β-cells from induced pluripotent stem cells as a potential cure for diabetes mellitus
Diabetes mellitus (DM) is a group of metabolic disorders characterized by high blood
glucose levels due to insufficient insulin secretion, insulin action, or both. The present-day …
glucose levels due to insufficient insulin secretion, insulin action, or both. The present-day …
Exploring biomarkers and transcriptional factors in type 2 diabetes by comprehensive bioinformatics analysis on RNA-Seq and scRNA-Seq data
Y Huang, L Cai, X Liu, Y Wu… - Annals of Translational …, 2022 - pmc.ncbi.nlm.nih.gov
Background Type 2 diabetes (T2D) is a prevalent chronic disease with elusive. Combining
transcriptome and single-cell sequencing data to explore biomarkers of T2D could provide …
transcriptome and single-cell sequencing data to explore biomarkers of T2D could provide …
[HTML][HTML] An artificial intelligence prediction model of insulin sensitivity, insulin resistance, and diabetes using genes obtained through differential expression
Insulin is a powerful pleiotropic hormone that affects processes such as cell growth, energy
expenditure, and carbohydrate, lipid, and protein metabolism. The molecular mechanisms …
expenditure, and carbohydrate, lipid, and protein metabolism. The molecular mechanisms …