The evolution and biology of SARS-CoV-2 variants
Our understanding of the still unfolding severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) pandemic would have been extremely limited without the study of the …
(SARS-CoV-2) pandemic would have been extremely limited without the study of the …
Probing the dynamic RNA structurome and its functions
RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …
molecules are thought to be central to their functions. The recent fast-paced evolution of high …
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy
The December 2019 outbreak of a novel respiratory virus, SARS-CoV-2, has become an
ongoing global pandemic due in part to the challenge of identifying symptomatic …
ongoing global pandemic due in part to the challenge of identifying symptomatic …
Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic
KKW To, S Sridhar, KHY Chiu, DLL Hung… - Emerging microbes & …, 2021 - Taylor & Francis
Without modern medical management and vaccines, the severity of the Coronavirus
Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) …
Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) …
Advances and opportunities in RNA structure experimental determination and computational modeling
Beyond transferring genetic information, RNAs are molecules with diverse functions that
include catalyzing biochemical reactions and regulating gene expression. Most of these …
include catalyzing biochemical reactions and regulating gene expression. Most of these …
Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells
SARS-CoV-2 is a betacoronavirus with a single-stranded, positive-sense, 30-kilobase RNA
genome responsible for the ongoing COVID-19 pandemic. Although population average …
genome responsible for the ongoing COVID-19 pandemic. Although population average …
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms
Summary Severe-acute-respiratory-syndrome-related coronavirus 2 (SARS-CoV-2) is the
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design
B Malone, N Urakova, EJ Snijder… - … Reviews Molecular Cell …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed millions of
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …
people and continues to cause massive global upheaval. Coronaviruses are positive-strand …
Predicting the mutational drivers of future SARS-CoV-2 variants of concern
SARS-CoV-2 evolution threatens vaccine-and natural infection–derived immunity and the
efficacy of therapeutic antibodies. To improve public health preparedness, we sought to …
efficacy of therapeutic antibodies. To improve public health preparedness, we sought to …
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
K Leppek, GW Byeon, W Kladwang… - Nature …, 2022 - nature.com
Therapeutic mRNAs and vaccines are being developed for a broad range of human
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …
diseases, including COVID-19. However, their optimization is hindered by mRNA instability …