Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …
urgent due to the development of malignancies that are resistant to chemotherapeutic …
Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: in vitro studies
A unique series of pyrazolyl-chalcone derivatives was synthesized via the method of Claisen–
Schmidt condensation. The desired chalcone derivatives 7a–d and 9a–f were obtained in …
Schmidt condensation. The desired chalcone derivatives 7a–d and 9a–f were obtained in …
Green, facile synthesis and evaluation of unsymmetrical carbamide derivatives as antimicrobial and anticancer agents with mechanistic insights
A very practical method for the synthesis of unsymmetrical carbamide derivatives in good to
excellent yield was presented, without the need for any catalyst and at room temperature …
excellent yield was presented, without the need for any catalyst and at room temperature …
Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA …
MG Kamel, FM Sroor, MKH Hanafy, KF Mahrous… - RSC …, 2024 - pubs.rsc.org
Less than 5% of pancreatic cancer patients survive for more than five years after diagnosis.
Therefore, there is an urgent need for novel therapeutic drugs to treat pancreatic cancer …
Therefore, there is an urgent need for novel therapeutic drugs to treat pancreatic cancer …
New 2, 4-diaryl-3-azabicyclo [3.3. 1] nonan-9-one derivatives as antimicrobial and anti-cancer agents: synthesis, in-vitro and SAR studies
A new series of biologically active 2, 4-diphenyl-N-(4-(thiophen-2-yl) thiazol-2-yl)-3-
azabicyclo [3.3. 1] nonan-9-imine and N-(4-(naphthalen-2-yl) thiazol-2-yl)-2, 4-diphenyl-3 …
azabicyclo [3.3. 1] nonan-9-imine and N-(4-(naphthalen-2-yl) thiazol-2-yl)-2, 4-diphenyl-3 …
New cyano-acrylamide derivatives incorporating the thiophene moiety: Synthesis, anti-cancer, gene expression, DNA fragmentation, DNA damage, and in silico …
FM Sroor, HKA Elhakim, SM Abdelrehim… - Journal of Molecular …, 2025 - Elsevier
New cyano-acrylamide derivatives bearing the thiophene moiety were prepared and
rigorously characterized. Thus, the reaction of diethyl 5-(2-cyanoacetamido)-3 …
rigorously characterized. Thus, the reaction of diethyl 5-(2-cyanoacetamido)-3 …
Bis-aldehydes: Versatile precursors for bis-heterocycles
The widest variety of organic molecules, with major uses in industry, biomedicine, and
chemistry, are heterocycles. They can be found as scaffolds in several medications and …
chemistry, are heterocycles. They can be found as scaffolds in several medications and …
Design, synthesis, in vitro anticancer, molecular docking and SAR studies of new series of pyrrolo[2,3-d]pyrimidine derivatives
The current study involves the design and synthesis of a newly synthesized pyrrolo [2, 3-d]
pyrimidine derivatives to contain chlorine atoms in positions 4 and 6 and trichloromethyl …
pyrimidine derivatives to contain chlorine atoms in positions 4 and 6 and trichloromethyl …
Evaluation of Pyrazolyl‐Indolizine Derivatives as Antimicrobial Agents: Synthesis, In vitro, In silico ADMET and Molecular Docking Studies
SS Mukhtar, FM Sroor, TS Hafez… - Chemistry & …, 2024 - Wiley Online Library
Herein, we report analogues of s‐indacene by the synthesis of novel indolizine derivatives.
Using chloroform as an appropriate solvent, sixteen derivatives of pyrazolyl‐indolizine (4 …
Using chloroform as an appropriate solvent, sixteen derivatives of pyrazolyl‐indolizine (4 …
Cytotoxic Effect of New (E)‐2‐Cyano‐N‐(tetrahydrobenzo[b]thiophen‐2‐yl)acrylamide Derivatives: Down‐Regulation of RBL2 and STAT2 and Triggering of DNA …
A novel series of 2‐cyano‐N‐(tetrahydrobenzo [b] thiophen‐2‐yl) acrylamide derivatives
were synthesized and their structures were confirmed using several spectral tools. All …
were synthesized and their structures were confirmed using several spectral tools. All …