Tackling COVID-19 with neutralizing monoclonal antibodies
Monoclonal antibodies (mAbs) have revolutionized the treatment of several human
diseases, including cancer and autoimmunity and inflammatory conditions, and represent a …
diseases, including cancer and autoimmunity and inflammatory conditions, and represent a …
[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2
P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …
The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle
S Ricciardi, AM Guarino, L Giaquinto, EV Polishchuk… - Nature, 2022 - nature.com
Abstract SARS-CoV-2, like other coronaviruses, builds a membrane-bound replication
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …
organelle to enable RNA replication. The SARS-CoV-2 replication organelle is composed of …
[HTML][HTML] Evolution of antibody immunity to SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million
individuals and is responsible for over 1.7 million deaths to date. Infection is associated with …
individuals and is responsible for over 1.7 million deaths to date. Infection is associated with …
[HTML][HTML] Molecular architecture of the SARS-CoV-2 virus
SARS-CoV-2 is an enveloped virus responsible for the COVID-19 pandemic. Despite recent
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …
Structures and distributions of SARS-CoV-2 spike proteins on intact virions
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by
a lipid bilayer from which spike (S) protein trimers protrude. Heavily glycosylated S trimers …
a lipid bilayer from which spike (S) protein trimers protrude. Heavily glycosylated S trimers …
SARS-CoV-2: from its discovery to genome structure, transcription, and replication
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia
COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single …
COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single …
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in
humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we …
humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we …
The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein
The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …
Cryo-electron tomography on focused ion beam lamellae transforms structural cell biology
Cryogenic electron microscopy and data processing enable the determination of structures
of isolated macromolecules to near-atomic resolution. However, these data do not provide …
of isolated macromolecules to near-atomic resolution. However, these data do not provide …