There is an increasing appreciation that every cell, even of the same type, is different. This
complexity, when additionally combined with the variety of different cell types in tissue, is …

Membrane lateral heterogeneity is accepted as a requirement for the function of biological
membranes and the notion of lipid rafts gives specificity to this broad concept. However, the …

Common organic matrix-assisted laser desorption/ionization (MALDI) matrices, 2, 5-
dihydroxybenzoic acid, 3, 5-dimethoxy-4-hydroxycinnamic acid, and α-cyano-4 …

Modern mass spectrometry-the instrumentation and applications in diverse fields Mass
spectrometry has played a pivotal role in a variety of scientific disciplines. Today it is an …

Fundamental advances in secondary ion mass spectrometry (SIMS) now allow for the
examination and characterization of lipids directly from biological materials. The successful …

The ability of mass spectrometry to generate intact biomolecular ions efficiently in the gas
phase has led to its widespread application in metabolomics, proteomics, biological …

A droplet pickup and other mechanisms have been suggested for the ionization of
biomolecules like peptides and proteins by desorption electrospray ionization. To verify this …

Imaging Mass Spectrometry (IMS) is strengthening its position as a valuable analytical tool. It
has unique ability to identify structures and to unravel molecular changes that occur in the …

Mass spectrometry imaging (MSI) has become an important analytical tool for the label‐free
chemical imaging of diverse molecules in biological specimens. This minireview surveys …

Cluster secondary ion mass spectrometry (cluster SIMS) has played a critical role in the
characterization of polymeric materials over the last decade, allowing for the ability to obtain …