Angiogenesis Page 1 CHAPTER 42 Angiogenesis JUDAH FOLKMAN I. Introduction
Angiogenesis is the generation of new capillary blood vessels. While all subsequent vessels …

PURPOSE: Activation of the KIT tyrosine kinase by somatic mutation has been documented
in a number of human malignancies, including gastrointestinal stromal tumor (GIST) …

To assess the prognostic relevance of activating mutations of the FLT3 gene in
homogeneously treated adults 16 to 60 years of age with acute myeloid leukemia (AML) and …

Kaposi's sarcoma (KS) is a mesenchymal tumour involving blood and lymphatic vessels.
Only recently has the pathogenesis of this extraordinary neoplasm been elucidated. Viral …

Von Willebrand disease (VWD) type 1 is reported to be common but frequently is difficult to
diagnose. Many people have nonspecific mild bleeding symptoms, von Willebrand factor …

VEGF is a secreted growth factor that mediates its biological effects by binding to two
transmembrane tyrosine kinase receptors, VEGFR-1 and VEGFR-2. The VEGF/receptor …

Targeting angiogenesis represents a new strategy for the development of anticancer
therapies. New targets derived from proliferating endothelial cells may be useful in …

Neoangiogenesis has been shown to play an important role in the pathogenesis of acute
myeloid leukemia (AML). Autocrine and paracrine secretion of angiogenic and …

Vascular endothelial growth factor (VEGF) and its cellular receptor VEGFR-2 have been
implicated as the main endothelial pathway required for tumor neovascularization. However …

Vascular endothelial growth factor (VEGF) and its receptors (VEGFR) have been implicated
in promoting solid tumor growth and metastasis via stimulating tumor-associated …