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The genetics of bipolar disorder
FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
Epigenetic mechanisms of major depression: targeting neuronal plasticity
S Uchida, H Yamagata, T Seki… - Psychiatry and clinical …, 2018 - Wiley Online Library
Major depressive disorder is one of the most common mental illnesses as it affects more
than 350 million people globally. Major depressive disorder is etiologically complex and …
than 350 million people globally. Major depressive disorder is etiologically complex and …
Circuit-wide transcriptional profiling reveals brain region-specific gene networks regulating depression susceptibility
Depression is a complex, heterogeneous disorder and a leading contributor to the global
burden of disease. Most previous research has focused on individual brain regions and …
burden of disease. Most previous research has focused on individual brain regions and …
Efficacy of prospective pharmacogenetic testing in the treatment of major depressive disorder: results of a randomized, double-blind clinical trial
V Pérez, A Salavert, J Espadaler, M Tuson, J Saiz-Ruiz… - BMC psychiatry, 2017 - Springer
Abstract Background A 12-week, double-blind, parallel, multi-center randomized controlled
trial in 316 adult patients with major depressive disorder (MDD) was conducted to evaluate …
trial in 316 adult patients with major depressive disorder (MDD) was conducted to evaluate …
Clinical implementation of pharmacogenetic decision support tools for antidepressant drug prescribing
The accrual and analysis of genomic sequencing data have identified specific genetic
variants that are associated with major depressive disorder. Moreover, substantial …
variants that are associated with major depressive disorder. Moreover, substantial …
Depression: Biological markers and treatment
Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …
mechanisms involved in its etiology, including inflammatory response, hypothalamic …
Does pharmacogenomic testing improve clinical outcomes for major depressive disorder? A systematic review of clinical trials and cost-effectiveness studies
Objective: Pharmacogenomic testing has become scalable and available to the general
public. Pharmacogenomics has shown promise for predicting antidepressant response and …
public. Pharmacogenomics has shown promise for predicting antidepressant response and …
Pharmacogenomics in the treatment of mood disorders: strategies and opportunities for personalized psychiatry
Personalized medicine (personalized psychiatry in a specific setting) is a new model
towards individualized care, in which knowledge from genomics and other omic pillars …
towards individualized care, in which knowledge from genomics and other omic pillars …
Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies
Cytochrome (CYP) P450 enzymes have a primary role in antidepressant metabolism and
variants in these polymorphic genes are targets for pharmacogenetic investigation. This is …
variants in these polymorphic genes are targets for pharmacogenetic investigation. This is …
TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics
Millions of patients suffer from major depressive disorder (MDD), but many do not respond to
selective serotonin reuptake inhibitor (SSRI) therapy. We used a pharmacometabolomics …
selective serotonin reuptake inhibitor (SSRI) therapy. We used a pharmacometabolomics …