Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …

Cardiac fibroblasts constitute a major cell population in the heart. They secrete extracellular
matrix components and various other factors sha** the microenvironment of the heart. In …

Mitochondrial dysfunction is a hallmark of heart failure. Mitochondrial transplantation has
been demonstrated to be able to restore heart function, but its mechanism of action remains …

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) are
powerful in vitro models to study the mechanisms underlying cardiomyopathies and …

The most advanced in vitro cardiac models are today based on the use of induced
pluripotent stem cells (iPSCs); however, the maturation of cardiomyocytes (CMs) has not yet …

Cardiomyocytes differentiated from human induced Pluripotent Stem Cells (hiPSC-CMs) are
a unique source for modelling inherited cardiomyopathies. In particular, the possibility of …

Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by the
lack of dystrophin. Heart failure, driven by cardiomyocyte death, fibrosis, and the …

The quest for novel methods to mature human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) for cardiac regeneration, modelling and drug testing has …

Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

Background Adipose tissue homeostasis is at the heart of many metabolic syndromes such
as diabetes. Previously it has been demonstrated that adipose tissues from diabetic patients …