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Chemistry and biology of multicomponent reactions
A Domling, W Wang, K Wang - Chemical reviews, 2012 - ACS Publications
Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …
[HTML][HTML] Mechanochemical synthesis of small organic molecules
With the growing interest in renewable energy and global warming, it is important to
minimize the usage of hazardous chemicals in both academic and industrial research …
minimize the usage of hazardous chemicals in both academic and industrial research …
50th Anniversary Perspective: Polymer Functionalization
The translation of small molecule chemistries into efficient methodologies for polymer
functionalization spans several decades, enabling critical advances in soft matter materials …
functionalization spans several decades, enabling critical advances in soft matter materials …
Principle and design of pseudo-natural products
Natural products (NPs) are a significant source of inspiration towards the discovery of new
bioactive compounds based on novel molecular scaffolds. However, there are currently only …
bioactive compounds based on novel molecular scaffolds. However, there are currently only …
Multicomponent reaction design in the quest for molecular complexity and diversity
E Ruijter, R Scheffelaar… - Angewandte Chemie …, 2011 - Wiley Online Library
Multicomponent reactions have become increasingly popular as tools for the rapid
generation of small‐molecule libraries. However, to ensure sufficient molecular diversity and …
generation of small‐molecule libraries. However, to ensure sufficient molecular diversity and …
Biginelli reaction: an overview
Biginelli reaction involves acid-catalyzed one-pot synthesis of 3, 4-dihydropyrimidin-2 (1 H)-
ones (DHPMs) using easily-accessible starting materials, namely, aldehyde, active …
ones (DHPMs) using easily-accessible starting materials, namely, aldehyde, active …
Catalyst-free mechanochemistry as a versatile tool in synthetic chemistry: a review
A notable advancement of the mechanochemical process has been its ability to initiate
reactions that are otherwise extremely difficult/impossible to accomplish. For the first time, in …
reactions that are otherwise extremely difficult/impossible to accomplish. For the first time, in …
Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis
Catalyst-free reactions developed during the last decade and the latest developments in this
emerging field are summarized with a focus on catalyst-free reactions in-water and on-water …
emerging field are summarized with a focus on catalyst-free reactions in-water and on-water …
[HTML][HTML] Recent developments on ultrasound-assisted one-pot multicomponent synthesis of biologically relevant heterocycles
B Banerjee - Ultrasonics sonochemistry, 2017 - Elsevier
Heterocycles are the backbone of organic compounds. Specially, N-& O-containing
heterocycles represent privileged structural subunits well distributed in naturally occurring …
heterocycles represent privileged structural subunits well distributed in naturally occurring …
Biologically active dihydropyrimidones of the Biginelli-type—a literature survey
CO Kappe - European journal of medicinal chemistry, 2000 - Elsevier
In 1893, the synthesis of functionalized 3, 4-dihydropyrimidin-2 (1H)-ones (DHPMs) via three-
component condensation reaction of an aromatic aldehyde, urea and ethyl acetoacetate …
component condensation reaction of an aromatic aldehyde, urea and ethyl acetoacetate …