Chemistry and biology of multicomponent reactions

A Domling, W Wang, K Wang - Chemical reviews, 2012 - ACS Publications
Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

[HTML][HTML] Mechanochemical synthesis of small organic molecules

TK Achar, A Bose, P Mal - Beilstein journal of organic …, 2017 - beilstein-journals.org
With the growing interest in renewable energy and global warming, it is important to
minimize the usage of hazardous chemicals in both academic and industrial research …

50th Anniversary Perspective: Polymer Functionalization

E Blasco, MB Sims, AS Goldmann, BS Sumerlin… - …, 2017 - ACS Publications
The translation of small molecule chemistries into efficient methodologies for polymer
functionalization spans several decades, enabling critical advances in soft matter materials …

Principle and design of pseudo-natural products

G Karageorgis, DJ Foley, L Laraia, H Waldmann - Nature Chemistry, 2020 - nature.com
Natural products (NPs) are a significant source of inspiration towards the discovery of new
bioactive compounds based on novel molecular scaffolds. However, there are currently only …

Multicomponent reaction design in the quest for molecular complexity and diversity

E Ruijter, R Scheffelaar… - Angewandte Chemie …, 2011 - Wiley Online Library
Multicomponent reactions have become increasingly popular as tools for the rapid
generation of small‐molecule libraries. However, to ensure sufficient molecular diversity and …

Biginelli reaction: an overview

H Nagarajaiah, A Mukhopadhyay, JN Moorthy - Tetrahedron Letters, 2016 - Elsevier
Biginelli reaction involves acid-catalyzed one-pot synthesis of 3, 4-dihydropyrimidin-2 (1 H)-
ones (DHPMs) using easily-accessible starting materials, namely, aldehyde, active …

Catalyst-free mechanochemistry as a versatile tool in synthetic chemistry: a review

BR Naidu, T Sruthi, R Mitty, K Venkateswarlu - Green Chemistry, 2023 - pubs.rsc.org
A notable advancement of the mechanochemical process has been its ability to initiate
reactions that are otherwise extremely difficult/impossible to accomplish. For the first time, in …

Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis

MB Gawande, VDB Bonifácio, R Luque… - Chemical Society …, 2013 - pubs.rsc.org
Catalyst-free reactions developed during the last decade and the latest developments in this
emerging field are summarized with a focus on catalyst-free reactions in-water and on-water …

[HTML][HTML] Recent developments on ultrasound-assisted one-pot multicomponent synthesis of biologically relevant heterocycles

B Banerjee - Ultrasonics sonochemistry, 2017 - Elsevier
Heterocycles are the backbone of organic compounds. Specially, N-& O-containing
heterocycles represent privileged structural subunits well distributed in naturally occurring …

Biologically active dihydropyrimidones of the Biginelli-type—a literature survey

CO Kappe - European journal of medicinal chemistry, 2000 - Elsevier
In 1893, the synthesis of functionalized 3, 4-dihydropyrimidin-2 (1H)-ones (DHPMs) via three-
component condensation reaction of an aromatic aldehyde, urea and ethyl acetoacetate …