Executive function in Down syndrome: A meta-analysis

AS Tungate, FA Conners - Research in developmental disabilities, 2021 - Elsevier
Background Executive function (EF) refers to a set of cognitive processes involved in goal-
oriented behavior—especially inhibition, attention shifting, and working memory. EF has …

Neurodevelopment in Down syndrome: Concordance in humans and models

JA Klein, TF Haydar - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Great strides have been made over the past 30 years in understanding the
neurodevelopmental changes underlying the intellectual disability (ID) in Down syndrome …

Altered cell and RNA isoform diversity in aging Down syndrome brains

CR Palmer, CS Liu, WJ Romanow, MH Lee… - Proceedings of the …, 2021 - pnas.org
Down syndrome (DS), trisomy of human chromosome 21 (HSA21), is characterized by
lifelong cognitive impairments and the development of the neuropathological hallmarks of …

Validation of the NIH Toolbox Cognitive Battery in intellectual disability

RH Shields, AJ Kaat, FJ McKenzie, A Drayton… - Neurology, 2020 - neurology.org
Objective To advance the science of cognitive outcome measurement for individuals with
intellectual disability (ID), we established administration guidelines and evaluated the …

Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome

EC Utagawa, DG Moreno, KT Schafernak… - Acta neuropathologica …, 2022 - Springer
Although Down syndrome (DS), the most common developmental genetic cause of
intellectual disability, displays proliferation and migration deficits in the prenatal frontal …

Response inhibition and interference suppression in individuals with down syndrome compared to typically develo** children

L Traverso, M Fontana, MC Usai… - Frontiers in …, 2018 - frontiersin.org
The present study aims to investigate inhibition in individuals with Down Syndrome
compared to typically develo** children with different inhibitory tasks tap** response …

[HTML][HTML] The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome …

MM Ahmed, ACJ Wang, M Elos, HJ Chial, S Sillau… - Neurobiology of …, 2022 - Elsevier
Down syndrome (DS) is characterized by chronic neuroinflammation, peripheral
inflammation, astrogliosis, imbalanced excitatory/inhibitory neuronal function, and cognitive …

From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome

LA Watson, HS Meharena - Frontiers in Genetics, 2023 - frontiersin.org
Down syndrome (DS), caused by triplication of chromosome 21, is the most frequent
aneuploidy observed in the human population and represents the most common genetic …

Distinct neuroanatomical and neuropsychological features of Down syndrome compared to related neurodevelopmental disorders: a systematic review

O Hamadelseed, MKS Chan, MBF Wong… - Frontiers in …, 2023 - frontiersin.org
Objectives We critically review research findings on the unique changes in brain structure
and cognitive function characteristic of Down syndrome (DS) and summarize the similarities …

Theory of Mind in children and adolescents with Down syndrome

I Neitzel, M Penke - Research in Developmental Disabilities, 2021 - Elsevier
Introduction To date, the evidence regarding False Belief (FB) abilities in individuals with
Down syndrome (DS) has been both sparse and contradictory. Our study is the first …