Is the HPA axis as target for depression outdated, or is there a new hope?
A Menke - Frontiers in psychiatry, 2019 - frontiersin.org
Major depressive disorder (MDD) is a very common stress-related mental disorder that
carries a huge burden for affected patients and the society. It is associated with a high …
carries a huge burden for affected patients and the society. It is associated with a high …
Substance P and pain chronicity
W Zieglgänsberger - Cell and tissue research, 2019 - Springer
Substance P (SP) is a highly conserved member of the tachykinin peptide family that is
widely expressed throughout the animal kingdom. The numerous members of the tachykinin …
widely expressed throughout the animal kingdom. The numerous members of the tachykinin …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
FKBP ligands—where we are and where to go?
JM Kolos, AM Voll, M Bauder, F Hausch - Frontiers in pharmacology, 2018 - frontiersin.org
In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
Hypothalamic–pituitary–adrenal axis and stress
C Leistner, A Menke - Handbook of clinical neurology, 2020 - Elsevier
Stress is associated with the onset of several stress-related mental disorders that occur more
frequently in women than in men, such as major depression or posttraumatic stress disorder …
frequently in women than in men, such as major depression or posttraumatic stress disorder …
The HPA axis as target for depression
A Menke - Current Neuropharmacology, 2024 - benthamdirect.com
Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime
prevalence of 20% and, thus, is one of the most prevalent mental health disorders …
prevalence of 20% and, thus, is one of the most prevalent mental health disorders …
Moderate aerobic exercise training prevents the augmented hepatic glucocorticoid response induced by high-fat diet in mice
J Dassonvalle, F Díaz-Castro… - International journal of …, 2020 - mdpi.com
Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is
associated with the development of obesity and metabolic syndrome. However, it is not …
associated with the development of obesity and metabolic syndrome. However, it is not …
Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice
Z Yao, Y Gong, W Chen, S Shao, Y Song, H Guo… - Nature …, 2023 - nature.com
Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However,
during insulin resistance (IR), when insulin signalling is blunted and accompanied by …
during insulin resistance (IR), when insulin signalling is blunted and accompanied by …
The many faces of FKBP51
The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress
responses in mammals and as a potential therapeutic target for stress-related disorders …
responses in mammals and as a potential therapeutic target for stress-related disorders …
FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention
FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its
members have fundamental roles in the regulation of signalling pathways involved in …
members have fundamental roles in the regulation of signalling pathways involved in …