SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions,
geared towards the rapid and reliable assembly of functional molecules. This review …

The reactions of organic azides and alkynes catalysed by copper species represent the
prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed …

Sulfur (vi) fluoride exchange (SuFEx) is a category of click chemistry that enables covalent
linking of modular units through sulfur (vi) connective hubs. The efficiency of SuFEx and the …

Selenium-based catalysts, due to their high efficiency, mild reaction conditions, good
functional compatibility and excellent selectivity, have attracted much attention during the …

Click chemistry, proposed nearly 20 years ago, promised access to novel chemical space by
empowering combinatorial library synthesis with a “few good reactions”. These click …

Since its discovery in 2002, the copper-catalyzed azide-alkyne cycloaddition (CuAAC)[1]
reaction—the most widely recognized example of click chemistry [2]—has been rapidly …

Heterocycles are an extraordinarily important class of compounds, making up more than half
of all known organic compounds. Heterocycles are present in a wide variety of drugs, most …

Pioneered by Huisgen in the 1960s, 1 the 1, 3-dipolar cycloaddition reaction between
acetylenes and azides was brought back into focus by Sharpless and others2 when they …

Despite enormous progress in the field of the synthetic chemistry involving, for example,
catalytic and combinatorial synthesis of a large libraries of compounds, multicomponent …

Phosphorus fluoride exchange (PFEx) represents a cutting-edge advancement in catalytic
click-reaction technology. Drawing inspiration from nature's phosphate connectors, PFEx …