Randomised clinical trials in critical care: past, present and future
Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …
Decision making in older adults with cancer
C DuMontier, KP Loh… - Journal of Clinical …, 2021 - ascopubs.org
Significant progress has been made toward improving the care of older adults with cancer.
As described elsewhere in this Special Series, the evidence base in geriatric oncology has …
As described elsewhere in this Special Series, the evidence base in geriatric oncology has …
Preventive psychiatry: a blueprint for improving the mental health of young people
Preventive approaches have latterly gained traction for improving mental health in young
people. In this paper, we first appraise the conceptual foundations of preventive psychiatry …
people. In this paper, we first appraise the conceptual foundations of preventive psychiatry …
Heterogeneity of treatment effects in an analysis of pooled individual patient data from randomized trials of device closure of patent foramen ovale after stroke
Importance Patent foramen ovale (PFO)–associated strokes comprise approximately 10% of
ischemic strokes in adults aged 18 to 60 years. While device closure decreases stroke …
ischemic strokes in adults aged 18 to 60 years. While device closure decreases stroke …
Redevelopment and validation of the SYNTAX score II to individualise decision making between percutaneous and surgical revascularisation in patients with complex …
Background Randomised controlled trials are considered the gold standard for testing the
efficacy of novel therapeutic interventions, and typically report the average treatment effect …
efficacy of novel therapeutic interventions, and typically report the average treatment effect …
Develo** clinical prediction models: a step-by-step guide
Predicting future outcomes of patients is essential to clinical practice, with many prediction
models published each year. Empirical evidence suggests that published studies often have …
models published each year. Empirical evidence suggests that published studies often have …
Evaluating treatment prioritization rules via rank-weighted average treatment effects
There are a number of available methods for selecting whom to prioritize for treatment,
including ones based on treatment effect estimation, risk scoring, and hand-crafted rules. We …
including ones based on treatment effect estimation, risk scoring, and hand-crafted rules. We …
Effectiveness of molnupiravir and nirmatrelvir–ritonavir in hospitalized patients with COVID-19: a target trial emulation study
Background: Whether hospitalized patients benefit from COVID-19 oral antivirals is
uncertain. Objective: To examine the real-world effectiveness of molnupiravir and …
uncertain. Objective: To examine the real-world effectiveness of molnupiravir and …
Heterogeneous treatment effects of therapeutic-dose heparin in patients hospitalized for COVID-19
Importance Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients
hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of …
hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of …
Effects on mortality and major bleeding of radial versus femoral artery access for coronary angiography or percutaneous coronary intervention: meta-analysis of …
Background: In some randomized clinical trials, transradial access (TRA) compared with
transfemoral access (TFA) was associated with lower mortality in patients with coronary …
transfemoral access (TFA) was associated with lower mortality in patients with coronary …