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FGF/FGFR signaling in health and disease
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …
signaling has crucial roles in a multitude of processes during embryonic development and …
The osteocyte as a signaling cell
Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …
Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression
Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …
disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling …
[HTML][HTML] Osteocyte-related cytokines regulate osteoclast formation and bone resorption
The process of bone remodeling is the result of the regulated balance between bone cell
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …
populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the …
The Klotho proteins in health and disease
Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …
FGF23 and klotho at the intersection of kidney and cardiovascular disease
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …
Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …
α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling
The ageing suppressor α-klotho binds to the fibroblast growth factor receptor (FGFR). This
commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and …
commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and …
The fibroblast growth factor signaling pathway
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions
The bone-derived hormone fibroblast growth factor 23 (FGF23) functions in concert with
parathyroid hormone (PTH) and the active vitamin D metabolite, 1, 25 (OH) 2 vitamin D (1 …
parathyroid hormone (PTH) and the active vitamin D metabolite, 1, 25 (OH) 2 vitamin D (1 …