Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies
Quantitative traits analyzed in Genome-Wide Association Studies (GWAS) are often
nonnormally distributed. For such traits, association tests based on standard linear …
nonnormally distributed. For such traits, association tests based on standard linear …
Genotype–covariate interaction effects and the heritability of adult body mass index
Obesity is a worldwide epidemic, with major health and economic costs. Here we estimate
heritability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated …
heritability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated …
Dissecting complex traits using omics data: A review on the linear mixed models and their application in GWAS
Genome-wide association study (GWAS) is the most popular approach to dissecting
complex traits in plants, humans, and animals. Numerous methods and tools have been …
complex traits in plants, humans, and animals. Numerous methods and tools have been …
DeepNull models non-linear covariate effects to improve phenotypic prediction and association power
Genome-wide association studies (GWASs) examine the association between genotype and
phenotype while adjusting for a set of covariates. Although the covariates may have non …
phenotype while adjusting for a set of covariates. Although the covariates may have non …
Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration
Streptococcus pneumoniae is a leading cause of invasive disease in infants, especially in
low-income settings. Asymptomatic carriage in the nasopharynx is a prerequisite for …
low-income settings. Asymptomatic carriage in the nasopharynx is a prerequisite for …
Efficient set tests for the genetic analysis of correlated traits
Set tests are a powerful approach for genome-wide association testing between groups of
genetic variants and quantitative traits. We describe mtSet (http://github. com/PMBio/limix), a …
genetic variants and quantitative traits. We describe mtSet (http://github. com/PMBio/limix), a …
Genome-wide association analysis identifies genetic loci associated with resistance to multiple antimalarials in Plasmodium falciparum from China-Myanmar border
Drug resistance has emerged as one of the greatest challenges facing malaria control. The
recent emergence of resistance to artemisinin (ART) and its partner drugs in ART-based …
recent emergence of resistance to artemisinin (ART) and its partner drugs in ART-based …
Integrating a genome‐wide association study with a large‐scale transcriptome analysis to predict genetic regions influencing the glycaemic index and texture in rice
Reliably generating rice varieties with low glycaemic index (GI) is an important nutritional
intervention given the high rates of Type II diabetes incidences in Asia where rice is staple …
intervention given the high rates of Type II diabetes incidences in Asia where rice is staple …
Genome-wide association analyses reveal the genetic basis of stigma exsertion in rice
Stigma exsertion, a key determinant of the rice mating system, greatly contributes to the
application of heterosis in rice. Although a few quantitative trait loci associated with stigma …
application of heterosis in rice. Although a few quantitative trait loci associated with stigma …
Genome‐wide association coupled gene to gene interaction studies unveil novel epistatic targets among major effect loci impacting rice grain chalkiness
Rice varieties whose quality is graded as excellent have a lower percent grain chalkiness
(PGC) of two per cent and below with higher whole grain yields upon milling, leading to …
(PGC) of two per cent and below with higher whole grain yields upon milling, leading to …