Extracellular vesicles, in particular the subclass exosomes, are rapidly emerging as a novel
therapeutic platform. However, currently very few clinical validation studies and no clearly …

Extracellular vesicles (EVs) are cell-derived biological nanoparticles that gained great
interest for drug delivery. EVs have numerous advantages compared to synthetic …

3D cell culture technologies have revolutionized our understanding of cellular behavior,
both in culture and in vivo, but adoption by cell-based screening groups has been slow …

The immunomodulatory properties of mesenchymal stem cells (MSCs) make them attractive
therapeutic agents for a wide range of diseases. However, the highly demanding cell doses …

Achieving a high cell density of animal cells is a prerequisite for different medical
applications such as cell therapy, tissue engineering, and vaccine production. Microcarrier …

Cell-based therapies have generated great interest in the scientific and medical
communities, and stem cells in particular are very appealing for regenerative medicine, drug …

Advances in stem cell biology have afforded promising results for the generation of various
cell types for therapies against devastating diseases. However, a prerequisite for realizing …

Therapeutic and industrial applications of pluripotent stem cells and their derivatives require
large cell quantities generated in defined conditions. To this end, we have translated single …

Chemotherapeutics continue to play a central role in the treatment of a wide variety of
cancers. Conventional chemotherapy involving bolus intravenous doses results in severe …

The large cell doses (> 1× 106 cells/kg) used in clinical trials with mesenchymal
stem/stromal cells (MSC) will require an efficient production process. Moreover, monitoring …