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Development of prefrontal cortex
During evolution, the cerebral cortex advances by increasing in surface and the introduction
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …
Developmental mechanisms underlying the evolution of human cortical circuits
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
higher cognitive functions. These capacities are tightly linked to an increase in the size and …
[HTML][HTML] A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …
[HTML][HTML] Exploring the role of neuroplasticity in development, aging, and neurodegeneration
Neuroplasticity refers to the ability of the brain to reorganize and modify its neural
connections in response to environmental stimuli, experience, learning, injury, and disease …
connections in response to environmental stimuli, experience, learning, injury, and disease …
An atlas of cortical arealization identifies dynamic molecular signatures
The human brain is subdivided into distinct anatomical structures, including the neocortex,
which in turn encompasses dozens of distinct specialized cortical areas. Early …
which in turn encompasses dozens of distinct specialized cortical areas. Early …
Shared and distinct transcriptomic cell types across neocortical areas
The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …
functionally distinct areas. To investigate the diversity of cell types across the mouse …
A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
The cortical patterning principle has been a long-standing question in neuroscience, yet
how this translates to macroscale functional specialization in the human brain remains …
how this translates to macroscale functional specialization in the human brain remains …
Development and functional diversification of cortical interneurons
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …
collection of cell types that are characterized by their unique spatial and temporal …
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis
have been challenging because diverse cell types at different stages of maturation and …
have been challenging because diverse cell types at different stages of maturation and …
New insights into the development of the human cerebral cortex
The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …
presumed to be responsible for the neuronal computations underlying complex phenomena …