Beyond autophagy: LC3-associated phagocytosis and endocytosis
Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …
Innate receptor activation patterns involving TLR and NLR synergisms in COVID-19, ALI/ARDS and sepsis cytokine storms: a review and model making novel …
Severe COVID-19 is characterized by a “cytokine storm”, the mechanism of which is not yet
understood. I propose that cytokine storms result from synergistic interactions among Toll …
understood. I propose that cytokine storms result from synergistic interactions among Toll …
Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration
Proper immune responses are critical for successful biomaterial implantation. Here, four
scales of honeycomb-like TiO2 structures were custom made on titanium (Ti) substrates to …
scales of honeycomb-like TiO2 structures were custom made on titanium (Ti) substrates to …
Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation
Age-related macular degeneration is a prevalent neuroinflammatory condition and a major
cause of blindness driven by genetic and environmental factors such as obesity. In diseases …
cause of blindness driven by genetic and environmental factors such as obesity. In diseases …
[HTML][HTML] Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet
The molecular circadian clock and symbiotic host-microbe relationships both evolved as
mechanisms that enhance metabolic responses to environmental challenges. The gut …
mechanisms that enhance metabolic responses to environmental challenges. The gut …
Nanostructured Titanium Implant Surface Facilitating Osseointegration from Protein Adsorption to Osteogenesis: The Example of TiO2 NTAs
Titanium implants have been widely applied in dentistry and orthopedics due to their
biocompatibility and resistance to mechanical fatigue. TiO2 nanotube arrays (TiO2 NTAs) on …
biocompatibility and resistance to mechanical fatigue. TiO2 nanotube arrays (TiO2 NTAs) on …
[HTML][HTML] Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies
X Liu, L Yin, S Shen, Y Hou - Genes & Diseases, 2023 - Elsevier
Chronic inflammation caused by persistent infections and metabolic disorders is thought to
contribute to the increased cancer risk and the accelerated cancer progression. Oppositely …
contribute to the increased cancer risk and the accelerated cancer progression. Oppositely …
Roles of eicosanoids in regulating inflammation and neutrophil migration as an innate host response to bacterial infections
Eicosanoids are lipid-based signaling molecules that play a unique role in innate immune
responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and …
responses. The multiple types of eicosanoids, such as prostaglandins (PGs) and …
Microbial phagocytic receptors and their potential involvement in cytokine induction in macrophages
Phagocytosis is an essential process for the uptake of large (> 0.5 µm) particulate matter
including microbes and dying cells. Specialized cells in the body perform phagocytosis …
including microbes and dying cells. Specialized cells in the body perform phagocytosis …
Gut microbiome in colorectal cancer: Clinical diagnosis and treatment
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and the leading
cause of cancer-associated deaths. Epidemiological studies have shown that both genetic …
cause of cancer-associated deaths. Epidemiological studies have shown that both genetic …