Making a good egg: human oocyte health, aging, and in vitro development
Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …
Hippo signaling in the ovary: emerging roles in development, fertility, and disease
Emerging studies indicate that the Hippo pathway, a highly conserved pathway that
regulates organ size control, plays an important role in governing ovarian physiology …
regulates organ size control, plays an important role in governing ovarian physiology …
In vitro activation early follicles: from the basic science to the clinical perspectives
KCT Vo, K Kawamura - International Journal of Molecular Sciences, 2021 - mdpi.com
Development of early follicles, especially the activation of primordial follicles, is strictly
modulated by a network of signaling pathways. Recent advance in ovarian physiology has …
modulated by a network of signaling pathways. Recent advance in ovarian physiology has …
Implications of nonphysiological ovarian primordial follicle activation for fertility preservation
In recent years, ovarian tissue cryopreservation has rapidly developed as a successful
method for preserving the fertility of girls and young women with cancer or benign conditions …
method for preserving the fertility of girls and young women with cancer or benign conditions …
The late effects of cancer treatment on female fertility and the current status of fertility preservation—a narrative review
Fertility counseling should be offered to all individuals of young reproductive age early in the
patient's trajectory following a cancer diagnosis. Systemic cancer treatment and …
patient's trajectory following a cancer diagnosis. Systemic cancer treatment and …
Pathways coordinating oocyte attrition and abundance during mammalian ovarian reserve establishment
KJ Grive - Molecular Reproduction and Development, 2020 - Wiley Online Library
The mammalian ovarian reserve is comprised of a finite pool of primordial follicles,
representing the lifetime reproductive capacity of females. In most mammals, the reserve is …
representing the lifetime reproductive capacity of females. In most mammals, the reserve is …
Neurotrophin-4 promotes in vitro development and maturation of human secondary follicles yielding metaphase II oocytes and successful blastocyst formation
Y Guo, L Jia, H Zeng, P Sun, W Su, T Li… - Human …, 2024 - academic.oup.com
STUDY QUESTION Does a matrix-free culture system supplemented with neurotrophic
factor 4 (NT4) improve human in vitro follicular development and meiotic maturation …
factor 4 (NT4) improve human in vitro follicular development and meiotic maturation …
MALDI mass spectrometry imaging shows a gradual change in the proteome landscape during mouse ovarian folliculogenesis
Our knowledge regarding the role proteins play in the mutual relationship among oocytes,
surrounding follicle cells, stroma, and the vascular network inside the ovary is still poor and …
surrounding follicle cells, stroma, and the vascular network inside the ovary is still poor and …
Perfluorooctanoic acid (PFOA) promotes follicular growth and alters expression of genes that regulate the cell cycle and the Hippo pathway in cultured neonatal …
Perfluorooctanoic acid (PFOA) is a synthetic chemical resistant to biodegradation and is
environmentally persistent. PFOA is found in many consumer products and is a major source …
environmentally persistent. PFOA is found in many consumer products and is a major source …
The essential role of TAZ in normal tissue homeostasis
MG Jeong, HK Kim, ES Hwang - Archives of Pharmacal Research, 2021 - Springer
Transcriptional coactivator with PDZ-binding motif (TAZ) has been extensively characterized
in organ development, tissue regeneration, and tumor progression. In particular, TAZ …
in organ development, tissue regeneration, and tumor progression. In particular, TAZ …