Mitochondria-ER contact sites (MERCS) are known to underpin many important cellular
homoeostatic functions, including mitochondrial quality control, lipid metabolism, calcium …

Weak magnetic fields offer nearly lossless transmission of signals within biological tissue.
Magnetic nanomaterials are capable of transducing magnetic fields into a range of …

Exposure to environmental chemicals such as lead (Pb) during vulnerable developmental
periods can result in adverse health outcomes later in life. Human cohort studies have …

G protein-coupled receptors (GPCRs) detect compounds on the cell surface and are the
starting point of a number of medically relevant signaling cascades. Indeed, over 30% of …

Interpreting the wealth of rare genetic variants discovered in population-scale sequencing
efforts and deciphering their associations with human health and disease present a critical …

Fruit ripening and senescence are finely controlled by plant hormones such as ethylene and
abscisic acid (ABA) but also by calcium ions and by calcium-dependent signaling pathways …

Since the 1970s, the emergence and expansion of novel methods for calcium ion (Ca2+)
detection have found diverse applications in vitro and in vivo across a series of model …

Fluorescent proteins (FPs) are indispensable tools for noninvasive bioimaging and sensing.
Measuring the free cellular calcium (Ca2+) concentrations in vivo with genetically encodable …

Genetically-encoded fluorescent sensors have been actively developed over the last few
decades and used in live imaging and drug screening. Real-time monitoring of drug action …

Patients with heart failure often develop cardiac arrhythmias. The mechanisms and
interrelations linking heart failure and arrhythmias are not fully understood. Historically …