The physiology and genetics of bacterial responses to antibiotic combinations

R Roemhild, T Bollenbach, DI Andersson - Nature Reviews …, 2022 - nature.com
Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Size and charge effects of metal nanoclusters on antibacterial mechanisms

HT Draviana, I Fitriannisa, M Khafid… - Journal of …, 2023 - Springer
Nanomaterials, specifically metal nanoclusters (NCs), are gaining attention as a promising
class of antibacterial agents. Metal NCs exhibit antibacterial properties due to their …

Engineering Platelet Membrane‐Coated Bimetallic MOFs as Biodegradable Nanozymes for Efficient Antibacterial Therapy

Q Shi, Y Zhao, M Liu, F Shi, L Chen, X Xu, J Gao… - Small, 2024 - Wiley Online Library
Nanocatalytic‐based wound therapeutics present a promising strategy for generating
reactive oxygen species (ROS) to antipathogen to promote wound healing. However, the full …

Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections

U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

Surveying membrane landscapes: a new look at the bacterial cell surface

T Lithgow, CJ Stubenrauch, MPH Stumpf - Nature Reviews Microbiology, 2023 - nature.com
Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …

[書籍][B] An introduction to medicinal chemistry

GL Patrick - 2023 - books.google.com
Providing an introduction to medicinal chemistry, this resource covers basic principles and
background, and describes the general tactics and strategies involved in develo** an …

Outer membrane porins contribute to antimicrobial resistance in gram-negative bacteria

G Zhou, Q Wang, Y Wang, X Wen, H Peng, R Peng… - Microorganisms, 2023 - mdpi.com
Gram-negative bacteria depend on their cell membranes for survival and environmental
adaptation. They contain two membranes, one of which is the outer membrane (OM), which …

Third-generation tetracyclines: current knowledge and therapeutic potential

D Kounatidis, M Dalamaga, E Grivakou, I Karampela… - Biomolecules, 2024 - mdpi.com
Tetracyclines constitute a unique class of antibiotic agents, widely prescribed for both
community and hospital infections due to their broad spectrum of activity. Acting by …

Degradable hydrogel adhesives with enhanced tissue adhesion, superior self‐healing, cytocompatibility, and antibacterial property

Y Yang, K Shi, K Yu, F **ng, H Lai… - Advanced Healthcare …, 2022 - Wiley Online Library
Degradable hydrogel adhesives with multifunctional advantages are promising to be
candidates as hemostatic agents, surgical sutures, and wound dressings. In this study …

Targeting bacterial outer-membrane remodelling to impact antimicrobial drug resistance

NC Rosas, T Lithgow - Trends in Microbiology, 2022 - cell.com
The cell envelope is essential for survival and adaptation of bacteria. Bacterial membrane
proteins include the major porins that mediate the influx of nutrients and several classes of …