Pangenomic analysis identifies structural variation associated with heat tolerance in pearl millet

H Yan, M Sun, Z Zhang, Y **, A Zhang, C Lin, B Wu… - Nature Genetics, 2023 - nature.com
Pearl millet is an important cereal crop worldwide and shows superior heat tolerance. Here,
we developed a graph-based pan-genome by assembling ten chromosomal genomes with …

Artificial intelligence in cancer target identification and drug discovery

Y You, X Lai, Y Pan, H Zheng, J Vera, S Liu… - … and Targeted Therapy, 2022 - nature.com
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …

Physiological blood–brain transport is impaired with age by a shift in transcytosis

AC Yang, MY Stevens, MB Chen, DP Lee, D Stähli… - Nature, 2020 - nature.com
The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to
maintain brain function in part via its low transcellular permeability,–. Yet, recent studies …

Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion

E Gangoso, B Southgate, L Bradley, S Rus… - Cell, 2021 - cell.com
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which current
immunotherapy approaches have been unsuccessful. Here, we explore the mechanisms …

UniProt: a worldwide hub of protein knowledge

UniProt Consortium - Nucleic acids research, 2019 - academic.oup.com
Abstract The UniProt Knowledgebase is a collection of sequences and annotations for over
120 million proteins across all branches of life. Detailed annotations extracted from the …

Opportunities and challenges of using metagenomic data to bring uncultured microbes into cultivation

S Liu, CD Moon, N Zheng, S Huws, S Zhao, J Wang - Microbiome, 2022 - Springer
Although there is now an extensive understanding of the diversity of microbial life on earth
through culture-independent metagenomic DNA sequence analyses, the isolation and …

agriGO v2. 0: a GO analysis toolkit for the agricultural community, 2017 update

T Tian, Y Liu, H Yan, Q You, X Yi, Z Du… - Nucleic acids …, 2017 - academic.oup.com
The agriGO platform, which has been serving the scientific community for> 10 years,
specifically focuses on gene ontology (GO) enrichment analyses of plant and agricultural …