Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated
as natural byproducts during cellular processes, including metabolism. Under normal …

Abstract The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the
adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical …

Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Ferroptosis is triggered by a chain of intracellular labile iron‐dependent peroxidation of cell
membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and …

In this review, we have focused mainly on the study of their antioxidant and pro-oxidant
capacity, and the analysis of the oxidation of the catechol group to o-quinone. The redox …

Oxidative stress triggers ferroptosis, a form of cellular necrosis characterized by iron-
dependent lipid peroxidation, and has been implicated in Mycobacterium tuberculosis (Mtb) …

Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial
steps in the formation of ferroptosis include the accumulation of ferrous ions (Fe2+) and lipid …

Both genomic instability and the presence of chronic inflammation are involved in
carcinogenesis and tumor progression. These alterations predispose the cancer cells to …